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All About Drugs! PLEASE READ!
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All About Drugs! PLEASE READ!Posted:

connor122
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Joined: Jun 11, 200915Year Member
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Status: Offline
Joined: Jun 11, 200915Year Member
Posts: 879
Reputation Power: 37
I AM NOT TELLING ANYONE TO TAKE DRUGS! THIS IS FOR EDUCATIONAL PURPOSE ONLY!

Psychedelics
Cannabis-Hash: resin from the hemp-plant ("cannabis sativa") pressed together in little cubes or slices, colour ranges from light brown to black.
Weed (marihuana): dried flowering tops of the female hemp-plant, looks like dried flower-tops or (when cut:) tea-like, colour ranges from grey-green to brown-green.
Hash-oil:Concentrated extract from hash or marihuana.

Hemp is after alcohol and tobacco the most widely used drug. It is either smoked or eaten. The active ingredient is THC (tetrahydrocannabinol), the higher the THC-level the stronger the effects. Hash usually contains more THC than weed, hash-oil can contain up to 50% of THC.

Using a normal dose of hash or weed could have the following
effects:

* dry mouth, read eyes, a slightly accelerated heart-rate
* limbs feel heavy
* coordination seems difficult
* your present mood is intensified
* effects of a normal dose are also:
o carefree mood
o visual and auditive perception is intensified; music and surroundings get different (for the better).
o perception of time and space changes
o relaxation
o craving for (sweet) food
o having the giggles
o short-term memory is temporarily diminished
o fast-paced line of thought
* a higher dose results in:
o the above effects, but even stronger. Sometimes resulting in fear, or paranoia (bad trip). The only remedy is relaxation, a sweet drink, change of surroundings and (a) reassuring friend(s).
o nausea

Risks:

* Hash and weed are NOT physically addictive. In some cases (when hash and weed are used heavily) they could lead to mental dependence though.
* heavily using hash or weed could inhibit the psychological development in young people (using it just to forget problems, instead of solving them).
* smoking is always bad to your health
* smoking while pregnant is a bad idea
* there is the possibility of a bad trip, if too much is taken or if the set or setting are wrong.
* Driving while stoned is not a good idea.
* In many countries the use and possession of marihuana is illegal. Don't EVER cross a border while in possession of ANY drug (except alcohol and tobacco...).
* If you suffer from depressions, psychosis or anxiety, it's best not to use hemp.
Magic Mushrooms-WARNING: mushrooms should NEVER be ingested unless positively identified to be non-poisonous by a mycologist. Often the only differences between highly toxic mushrooms and edible mushrooms are extremely subtle and require a great deal of training to distinguish. Also, several hallucinogenic varieties have been shown to be toxic to humans in medium to large doses.

OH O-
| /
P
|
O CH
| / 3
// ___ _ CH CH N
| || || 2 2
| || || CH
\ / / 3
N
H PSILOCYBIN

For thousands of years before Europeans set foot in the New World the sacred mushroom was in use in native rituals. In the 1950s R. Gordon Wasson, a Wall Street banker, participated in a Mexico mushroom ceremony and eloquently described the 'Divine Inebriant' in a piece of writing which could go some way to explaining the fascination with which many people regard psychedelic drugs. These words, of course, could really equally apply to any of these substances:

'There are no apt words ... to characterize your state when you are, shall we say, 'bemushroomed.' ... How do you tell a man born blind what seeing is like? In the present case, this is especially true because superficially the bemushroomed man shows few of the objective symptoms of one intoxicated, drunk ... [the mushroom] permits you to see, more clearly than our pershing mortal eye can see, vistas beyond the horizons of this life, to travel backwards and forwards in time, even (as the Indians say) to know God. It is hardly surprising that your emotions are profoundly affected, and you feel that an indissoluble bond unites you with the others who have shared with you in the sacred agape ... All that you see during this night has a pristine quality: the landscape, the edifices, the carvings, the animals - they look as though they had come straight from the Maker's workshop. This newness of everything - it is as though the world had just dawned - overwhelms you and melts you with its beauty. Not unnaturally, what is happening to you seems to you freighted with significance, beside which the humdrum events of everyday are trivial ... What you are seeing and what you are hearing appear as one: the music assumes harmonious shape, giving visual form to its harmonies, and what you are seeing takes on the modalities of music - the music of the spheres ... All your senses are similarly affected: the cigarette with which you occasionally break the tension of the night smells as no cigarette before had ever smelled ; the glass of simple water is infinitely better than champagne.'

From 'The Hallucinogenic Fungi of Mexico', R. Gordon Wasson in The Psychedelic Reader, Ed. Gunther M. Weil et al, Citadel Press Inc., 1973.

Fortunately one does not have to visit Mexico to experience the mushrooms, probably the most effective and safest of natural psychedelics. Psilocybian mushrooms should not be confused with the Fly Agaric (amanita muscaria) a toxic deleriant. The most common species of 'Magic Mushroom' found wild in the UK is the increasingly popular 'Liberty Cap' (psilocybe senilanceata). Indeed this particular species, despite its relative weakness, is prized by the South American Indians as one of the best. The Liberty Cap contains psilocybin, which is converted to psilocin in the body. Psilocin is a close chemical relative of LSD. However, the effects, according to many users, are milder, more pleasant and there is said to be less risk of bad trips. The greatest danger comes from eating other mushrooms -- different poisonous mushrooms picked by mistake. Therefore any potential mushroom picker should be quite sure they know what to look for (many reference books about mushrooms describe the Liberty Cap). The season for the mushroom is between September and December. During this time many people, not known for a previous interest in fungi, can be seen scanning the grass in fields with bent heads. The mushrooms are usually found after heavy rain and a long search. After picking they are dried on paper. Although the dried mushrooms are less potent than the fresh, if not dried the mushrooms might contain flies harmful to the liver.

Some people say mushrooms make them sick, but then I have never had any toxic effects from the mushrooms. A test for psilocybin-containing mushrooms is to look for a blue colour at the end of the stem after they have been picked. Those who want to make quite sure can buy a chemical called methaminophenol sulphate from photographic positive identification. Add it to twenty times its volume in distilled water. Apply to stem of mushroom and wait half an hour for a deep purple colour.

The American mushrooms include Psilocybe cubensis and caerulescens and are far more potent on a weight basis than the English ones. Whereas typical doses of the Liberty Cap are 25-50 dried little mushrooms, only a few grams of the American mushrooms ('shrooms) are needed. The effects, as with any drug, depend on the individual's body weight as well as the size and strength of the mushrooms. The mushrooms have a greater effect if a soup is made from them and also if taken on an empty stomach. To prepare a soup it is necessary to boil up the 'shrooms for ten minutes, add packet soup powder or instant coffee to hid the (disgusting) taste then drink the soup and repeat the process using the same mushrooms.

The effects start after about twenty minutes for soup and forty-five minutes when eaten. At low doses effects last about four hours and at higher doses up to six hours. Once the effects start to end they do so rapidly, unlike acid which seems to linger on a bit.

Possession of fresh mushrooms, in the UK is not illegal at the present. This may well change in the future. Even now possession of a preparation or product of the mushrooms is an offence. This includes drying mushrooms to a powder, crushing or boiling them. Mushrooms which are dried but are still intact are legal (excuse: 'I picked them like that, Officer. The sun must have dried them out, honest guv'.').

Kits to grow the mushrooms at home in jam jars are available from the USA by mail order. 'FS' has a 'Resource Guide' containing information about 43 companies selling every thing from mushroom videos to edible cultures and spore prints (more than 50!). The address is given in the bibliography. Judge Clive Callman ruled in 1983 test case that the cultivation of 'magic mushrooms' is legal in the UK, unfortunately it's also quite difficult. A friend once tried it and failed due to lack of sterile conditions.

Fly Agaric
This drug is only included to warn of its considerable dangers.

The Fly Agaric ('amanita muscaria') is the well-known red toadstool with white spots which appears in illustrations in fairy tales. It is not a true psychedelic drug and at best has unpleasant side effects. At worst it could kill you.

Effects are said to be dizziness, muscle twitching and possible vomiting after a half hour. This is followed by a drunken feeling and perhaps a light sleep lasting about two hours. Numbness may be present in the extremities. On waking feelings of great strength and hallucinations (especially of size) lasting about six hours have been reported. Overdoses can lead to convulsions, derangement, coma and amnesia. There are reports that this drug can cause ergotism, constriction of blood in the extremities of the bodies (e.g. nose, fingers etc) leading to gangrene. Death or permanent brain damage is possible from overdose (caused by respiratory paralysis). Kidney damage is also possible.

Neither the toadstool nor any preparation of it are controlled substances. They are not likely to be ever classified as such, since hopefully few will be foolish enough to try it.
Nutmeg-Family: Myristicaceae
Genus: Myristica
Species: fragrans

Usage: 5-20 grams of ground nutmeg is ingested. Fresh ground is best. Can also be taken in a "space paste" concoction (see below). Space paste is difficult/expensive to make and tastes like shit; however, it may actually decrease the side effects.

Effects: Possible nausea during first hour; may cause vomiting or diarrhea in isolated cases. Takes anywhere from one to five hours for effects to set in. Then expect severe cottonmouth, flushing of skin, severely bloodshot eyes, dilated pupils. Personally I compare it to a very, very heavy hash buzz. "Intense sedation". Impaired speech and motor functions. Hallucinations uncommon in average (5-10 gm) doses. Generally followed by long, deep, almost coma-like sleep (expect 16 hours of sleep afterward) and feelings of lethargy after sleep. May cause constipation, water retention. Safrole is carcinogenic and toxic to the liver.

History: Nutmeg was a very important trade item in the 15th and 16th centuries. It was a precious commodity due to the enormous medicinal properties of its seeds. Slaves on the ships bringing nutmeg to Europe got in trouble for eating part of the cargo. They knew that a few large kernels of nutmeg would bring them a pleasant, euphoric feeling, and relieved their weariness and pain. Nutmeg was even used when the feeble King Charles II almost died of a clot or hemorrhage. His death a few days later did nothing to detract from its useful reputation. Rumor spread through London that Nutmegs could act as an abortifacient. The ladies who procured abortions from nutmeg were called "nutmeg ladies."

Interaction precautions: MAO inhibitor

MAO stands for MonoAmine Oxidase, an enzyme that breaks down certain amines and renders them ineffective. MAO inhibitors, then, are substances that interfere with the action of monoamine oxidase, leaving the amines intact. If the amines in question are dangerous, they can cause nasty--even deadly--side effects. Furthermore, it is dangerous to combine MAO inhibitors. If you are taking a prescription drug that is a MAO inhibitor, like most anti-depressants, avoid using any substance listed as a MAO inhibitor here.

The bottom line is this: when using an MAO inhibiting drug, don't ingest anything that contains potentially dangerous amines, or any other MAO inhibitor. If a substance is listed as an MAO inhibitor here, it may be dangerous when used in combination with any of the following substances:

sedatives
tranquilizers
antihistamines
narcotics
alcohol
amphetamines (even diet pills)
asarone
nutmeg
macromerine
ephedrine
dill oil
parsley oil
wild fennel oil
cocoa
coffee (or any substance that contains large amounts of caffeine)
aged cheeses
any tyrosine-containing food
any other MAO inhibitor

Active Constituents: Methylenedioxy-substituted compounds: myristicin (non-amine precursor of 3-methoxy-4,5-methylenedioxyamphetamine [M-MDA]) elemicin, and safrole.
Yohimbe bark (aphrodisiac?)-Family: Rubiaceae
Genus: Corynanthe
Species: yohimbe

Usage: 6-10 teaspoons of shaved bark are boiled 10 minutes in 1 pt. water, strained and sipped slowly. Addition of 500 mg of vitamin C per cup makes it take effect more quickly and potently (probably by forming easily assimilated ascorbates of the alkaloids). Bark can also be smoked. Yohimbine hydrochloride, a refined powder version, can also be snuffed. Also available at many health/herb stores is a liquid extract.

Effects: Called "the most potent aphrodisiac known" and "the only true aphrodisiac". Whether aphrodisiacs exist outside of mythology or not is a topic for debate, as is the definition of "aphrodisiac". Anyway, first effects after 30 minutes (sooner with vitamin C) consist of warm, pleasant spinal shivers, followed by psychic stimulation, heightening of emotional and sexual feelings, mild perceptual changes without hallucinations, sometimes spontaneous erections. Some experience nausea during first 30 minutes. Sexual activity is especially pleasurable. According to one source "Bantu orgies have been known to last over a week" [Ed: don't they get hungry?]. Total experience lasts 2-4 hours, however, several experiences lasting up to 24 hours have been reported. Aftereffects include pleasant, relaxed feelings with no hangover, but difficulty sleeping for a few hours (probably largely due to the increased mental activity).

Since they sell the stuff in health food stores and I'm not sure what it's legitimate uses are, I'm willing to admit that I've tried it. My experience was worth repeating. This of course constitutes no endorsement on my part of illegal or legal drugs or of the use of yohimbe for any reason at all.

I ground about 7 teaspoons of shaved bark in a spice grinder (fresh grinding seems to help with release of the active ingredients) and then boiled it in a pint of water for about 10 minutes. The stuff absorbs a lot of water. Also, when freshly ground, you get some FINE FINE FINE particles. It took me a good 15 minutes to filter the stuff out through coffee filters (had to use a bunch of filters because it clogged them up so bad). The resulting brew was one of the top three worst things I've ever tasted in my life (the other two being calamus root and an abortive attempt at a kava kava concoction). It tasted kind of like bile. You can kill the taste if you put enough honey in the tea, but the aftertaste never goes away. As soon as you swallow it creeps up your throat; really gross. The fact that the stuff should be sipped slowly makes this even worse. I would recommend finding a REAL strong chaser, like pure lemon juice or maybe a mint leaf--something that obliterates all other taste in your mouth when you eat/drink/chew it, yet is tolerably pleasant tasting. I would swig/chew this chaser after every sip of yohimbe tea.

WARNING: The active ingredients in yohimbe are MAO inhibitors.
MAO stands for MonoAmine Oxidase, an enzyme that breaks down certain amines and renders them ineffective. MAO inhibitors, then, are substances that interfere with the action of monoamine oxidase, leaving the amines intact. If the amines in question are dangerous, they can cause nasty--even deadly--side effects. Furthermore, it is dangerous to combine MAO inhibitors. If you are taking a prescription drug that is an MAO inhibitor, like prozac or most anti-depressants, avoid using any substance listed as an MAO inhibitor here.

The bottom line is this: when using an MAO inhibiting drug, don't ingest anything that contains potentially dangerous amines, or any other MAO inhibitor. If a substance is listed as an MAO inhibitor here, it may be dangerous when used in combination with any of the following substances:

sedatives
tranquilizers
antihistamines
narcotics
alcohol
amphetamines (even diet pills)
asarone
nutmeg
macromerine
ephedrine
dill oil
parsley oil
wild fennel oil
cocoa
coffee (or any substance that contains large amounts of caffeine)
aged cheeses
any tyrosine-containing food
any other MAO inhibitor

User's account:
Anyway, I took the tea with vitamin C. About 20 minutes after I got done drinking it I felt some mild nausea (more in my throat than in my stomach), some mellow trippy effects (just mostly weird thoughts and vivid mental images--nothing near a hallucination, no LSD-like mind racing), also had some speedy effects (like being on 500 mg of caffeine--jitters, etc) and started getting a little "pressure" in the groin region. To make a long story short, the nausea was a bummer, and sex was incredible. Yohimbe completely changes the meaning of the word "orgasm" for men, anyway. I have no idea what a woman's reaction to it would be.

The sexual effects lasted about 4 hours (only because I was getting tired :^); the speedy effects decreased earlier than that, but I couldn't sleep at all that night (even when I was ready to), and I'm sure it was because of the yohimbe.

I also recently tried the yohimbe extract that they sell in health food stores. The stuff costs about $7/oz. It comes in one ounce bottles with screw-on eye-dropper caps. Recommended dose on the bottle is 3-20 drops up to three times a day. First time I tried it I took 35 drops with absolutely no effects. Recently, I took 100 drops mixed in orange juice. The stuff is tasteless in minute quantities, but at 100 drops/~8 oz. of OJ, it added a mildly bitter taste. Not too bad, tho--1000x better than the tea. Anyway, it didn't do anything, so I took another 50 drops, then another 50, and still no effects whatsoever. I wonder if the extract is even active.

I would advise yohimbe experimenters to use the tea form, and start out with 4 or five teaspoons of fresh ground bark, as the effects of 7 teaspoons were quite pronounced in me, and I am a 200 lb. male with a high tolerance for everything.

Interaction precautions: MAO inhibitor.
Active Constituents: Yohimbine, yohimbiline, ajmaline. (Note that yohimBE is the plant; yohimBINE is one of the chemical principles found in the plant.)
Cactï-For many years most of us have been aware of the psychoactive effects of Peyote. More recently in drug-oriented literature there have been numerous references to other cacti believed to have hallucinogenic properties. Among these are Donana from northern Mexico, San Pedro from the Andes, three related mescaline-bearing species from South America, and at least 15 species used by the Indians of Central Mexico as Peyote substitutes. Botanists and Chemists are now studying the constitutes of these cacti and are making some remarkable discoveries. In this guide we will consider each of these cacti and bring the reader up to date on what scientists have learn- ed about them. The various methods of using these cacti are also discussed. Directions are given for cultivating cacti and increasing the yield of mescaline and other alkaloids. There are instructions for extracting mesca- line from Peyote and San Pedro, and mixed alkaloids from Donana and other cacti. We also include a brief discussion of the legal aspects of these hallucinogenic cacti and give the names and addresses of legitimate suppliers from whom these plants can be obtained at reasonable prices.

mescaline, peyote and the law
Both mescaline and Peyote are illegal under the statutes of the Federal Government and most States. Members of the Native American Church are permitted the ritual use of peyote because they established it as a religious sacrament long before these laws came into existence. Members are not permitted to use mescaline, however. Several other cacti such as San Pedro also contain mescaline. Technically it would be illegal to possess these, but because they are common ornamental plants it is permissible to use these cacti for normal horticultural purposes. If a person should attempt to use any of these plants for a psychedelic experience, prosecution is possible. If he were to extract the mescaline from these, the alkaloid would definitely be contraband material. It is important that this point be made clear because the mescaline extraction process is given in this guide. To extract the alkaloids from Donana and other non-mescaline bearing cacti is not illegal. The information in this guide is presented for the sake of furthering knowledge. The Author can assume no responsibility for how anyone may apply it.

peyote
This spineless, tufted, blue-green, button-like cactus, known botanically as LOPHOPHORA WILLIAMSII, is the most famous of the hallucinogenic cacti. It grows wild from Central Mexico to Northern Texas. It's known history dates back to pre-Columbian times; possibly as early as 300 B.C. During the past two centuries the religious use of Peyote has spread northward into the United States and Canada among many of the Plains Indian Tribes such as the Navajo, Comanche, Sioux, and Kiowa. This cactus eventually came to replace the hallucinogenic but dangerous red mescal bean (SOPHORA SECUNDIFLORA) as a ceremonial sacrament. During the 1800's the North American Peyote ritual was standardized. By 1920 the ceremonial practices of most tribes were identical with only minor variations.

(Note: In Mexico there is a popular liquor called mescal. Many people believe that it is made from the Peyote cactus. Actually it is fermented from the Maguey plant, a large succulent of the Amaryllis family with sword-like leaves. This plant does not contain mescaline or related alkaloids.)

It was in 1896 that Arthur Heffter extracted mescaline from Peyote and tested it upon himself. This was the first hallucinogenic compound isolated by man. About 350 mg of mescaline is required for a psycho tropic experience, although definite effects can be felt from as little as 100 mg. Mescaline may comprise as much as six percent of the weight of the dried button, but is more often closer to one percent. An average dried button the diameter of a quarter weighs about 2 grams. it usually takes 6-10 of these buttons to gain the desired effect.

It has been noted that the peyote experience is quantitatively somewhat different than that of pure mescaline, the former being more physical than the latter. This is due to several of the other alkaloids present in the cactus. These include: HORDENINE, N-METHYLMESCALINE, N-ACETYLMESCALINE, PELLOTINE, ANHALININE, ANHALONINE, ANHALIDNINE, ANHALONIDINE, ANHALAMINE, O-METHYLANHALONIDINE, TYRAMINE, and LOPHOPHORINE. Not all of these substances have psycho pharmacological activity when administered singly. Some of them in combination apparently potentiate the effects of the mescaline and definitely alter some of the characteristics of the experience.

Two of these alkaloids - Hordenine and Tyramine - have been found to possess antibacterial activity, presumably because of their phenolic function. For ages the Huichol Indians have rubbed the juices of fresh peyote into wounds to prevent infection and to promote healing. The Tarahumara Indians consume small amounts of peyote to combat hunger, thirst and exhaustion especially while hunting. They have been known to run for days after a Deer with no food, water or rest. Peyote has many uses in folkloric medicine including the treatment of arthritis, consumption, influenza, intestinal disorders, diabetes, snake and scorpion bites and datura poisoning. The Huichol and other tribes recognize two forms of peyote. One is larger, more potent and more bitter than the other. They call it TZINOURITEHUA-HIKURI (peyote of the Gods). The smaller, more palatable, but milder buttons are called RHAITOUMUANITARI-HIKURI (peyote of the goddesses). The difference between the two forms may be due solely to how old the plants are. Alkaloids tend to accumulate in these cacti with age. It is possible, however, that the goddess peyote is a different species. Until recently botanists believed that the genus LOPHOPHORA consisted of a single but highly variable species. But in 1967 H.H. Bravo found near Queretaro in south-central Mexico another species which he named LOPHOPHORA DIFFUSA. This plant is yellow-green, soft, ribless and contains a somewhat different alkaloid mixture with far less mescaline that L. williamsi.

the experience
About half an hour after ingesting the buttons the first effects are felt. There is a feeling of strange intoxication and shifting consciousness with minor perceptual changes. There may also be strong physical effects, including respiratory pressure, muscle tension (especially face and neck muscles), and queasiness or possible nausea. Any unpleasant sensations should disappear within an hour. After this the state of altered consci- ousness begins to manifest itself. The experience may vary with the individual, but among the possible occurences are feelings of inner tran- quillity, oneness with life, heightened awareness, and rapid thought flow. During the next several hours these effects will deepen and become more visual. Colors may become more intense. Halos and auras may appear about things. Objects may seem larger, smaller , closer or more distant than they actually are. Often persons will notice little or no changes in visual perception while beholding the world about them, but upon closing their eyes they will see on their mind-screen wildly colorful and constant changing patterns. After several more hours the intensity of the exper- ience gradually relaxes. Thought becomes less rapid and diffuse and more ordered. In the Navajo peyote ritual this change of thought flow is used wisely. During the first part of the ceremony the participants submit to the feeling and let the peyote teach them. During the latter part of the ritual the mind turns to thoughtful contemplation and understanding with the conscious intellect what the peyote has taught the subconscious mind.

The entire experience may last from 6 to 12 hours depending upon the individual and the amount of the plant consumed. After all the peyote effects have passed there is no comedown. One is likely to feel pleasantly relaxed and much a peace with the world. Although there is usually no desire for food during the experience one would probably have a wholesome appetite afterwards.

Methods of use
The most common method of use is simply to chew up and swallow the fresh or dried buttons after removing the tufts and sand. This is the way it is almost always done at Indian ceremonies. Most people find the taste of this cactus unbearably bitter. The Indians, however, feel if ones heart is pure, the bitterness will not be tasted. Many have found that by not cringing from the taste, but rather letting ones senses plunge directly to the center of the bitterness, a sort of separation from the offensive flavor is exper- ienced. One is aware of the bitterness, but it no longer disturbs him. This is similar to the practice of bringing ones consciousness to the center of pain so that detachment may occur. It is not a difficult trick, but it takes some mental discipline. People who cannot endure the bitterness of peyote often go to various extremes to get it into the system without having to taste it. One fairly effective method is to drink unsweetened grapefruit juice while chewing it. The acids in the juice somewhat neutralize some of the bitter bases. Another method is to grind the dried buttons in a pepper grinder and pack the pulverized material into OOO capsules which are washed down with warm water. This is an effective method but it can take 20 capsules or more to get a 350mg dose of mescaline. Often people will boil the buttons in water for several hours to make a concentrated tea. A cup of this decoction can be swallowed in a few hasty gulps. Another preparation that is occasionally used is a jelly-type dessert made with the fresh or dried plant. If spoonfuls are swallowed whole the gelatine serves as a sort of shield protecting the taste buds from contact with the bitter material. It also slows down the the absorption of the drug in the digestive tract. This can be of value. It is generally recommended that anyone consuming peyote or mescaline ingest it gradually during a period of an hour or take two half doses 45 minutes apart. This is done to reduce the shock of the alkaloid to the system. Nausea or queasiness is sometimes experienced half an hour or so after taking peyote or mescaline. This usually passes in less than an hour. A sip of grapefruit juice will sometimes dispel the sick feeling. During the peyote ceremony Indians encourage vomiting rather than restraint if the urge presents itself. Throwing up, they believe, is a purging of both physical and spiritual ills. Most tribes fast for at least a day before taking peyote. This can also help to minimize gastric distress. One should not have eaten for at least 6 hours before taking either mescaline or peyote.

A method which avoids both the bitterness and the nausea is the rectal infusion. 8-16 grams of dried peyote is ground into a fine powder and boiled in a pint of water for 30 minutes. It is then strained and further boiled to reduce it's volume to one half pint. After cooling, this is taken as an enema using a small bulb syringe and retained for at least two hours. If there is any fecal matter in the lower bowel, a small cleansing enema should be taken and thoroughly expelled before having the peyote infusion. Otherwise much of the drug will be taken up by the feces and later voided.

Finding and picking peyote
The peyote cactus may be found in many areas throughout the Chihuahuan Desert from central Mexico to southern Texas. When a site is found where peyote grows it usually does so in abundance. Sometimes it grows in open sunlit places, but more often it is found in clusters under fairly large shrubs, among mesquite or creosote bushes or in the shade of large succu- lents.

The best time to harvest any cactus is after a long dry spell. The worst time is during or after a rainy period. The plants build up alkaloids during dry seasons and draw upon them for growth when the rains come. If the plants are harvested during or after a wet spell, the alkaloid content may have dropped below 50 percent. If you have a soil test kit, you can get a good indication of the potency of cacti growing wild. If the soil is rich in nitrogen, the plants are likely to be rich in alkaloids.

When harvesting peyote, many people uproot the entire plant. This is unnecessary and wasteful. The roots contain no mescaline. Some of these plants have taken a long time to reach their size. A cactus three inches in diameter may be more than 20 years old. To collect peyote properly the button should be cleanly decapitated slightly above ground level. When the roots are left intact new buds will form where the old was removed. These will eventually develop into full-size buttons which may be harvested as before. Faulty harvesting method have seriously depleted populations of this cactus. Because of the presence of several phenolic alkaloids peyote cacti do not spoil easily and may be kept in their fresh form for several weeks after harvesting. If they are to be kept longer than this they must be refrigerated, frozen, or dried. The enzymes which cause the harvested plant to eventually decompose also destroy the mescaline and other alkaloids. To dry peyote buttons lay them out in the hot sun or in an oven at 250 degrees F until completely devoid of moisture.

Other Peyote-type cacti of central Mexico
There are several cacti which are used by the Tarahumares and other tribes of central Mexico as substitutes for peyote. Many of these cacti are now under investigation for their alkaloidal content and psychopharmacological activity. Progress is somewhat retarded in the studies of the effects of these plants because almost all experimentation has been conducted on laboratory animals rather than humans. Some of these cacti have been found to contain mescaline and other related alkaloids with known sympathomimetic properties. Much further research is needed on these plants and their activity. However, we will attempt to bring the reader up to date on what is known about them at this time.

PEYOTILLO:
This small cactus is botanically called PELECYPHORA ASELLIFORMIS. It is also known sometimes as the hatchet cactus because of its oddly flattened tubercules. It is often found growing in the state of San Louis Potosi in central Mexico. The plant contains traces of mescaline too minute to have any effect. It also contains small amounts of anhalidine, anhaladine, hordenine, N-methylmescaline, pellotine, 3-demethyltrichocereine, B-phenethylamine, N-methyl-B-phenethylamine, 3,4-dimethoxy-B-pheneththyl- amine, N-methyl-3,4-dimethoxy-B-phenethylamine, and 4-methoxy-B-phenethy- lamine. Most of these are found in peyote but in much larger quantities.

TSUWIRI:
The botanical name of this cactus is ARIOCARPUS RETUSUS. The Huichol name tsuwiri means False Peyote. These people make long pilgrimages to the sacred places where peyote grows in search of that sacrement. They believe that if a person is has not been properly purified the spirits will lead him to the False Peyote and if he partakes of it, he will suffer madness or at least a bad trip. The plant is known among some tribes as Chautle or Chaute. These names are also used for other Ariocarpus species. This cactus contains hordenine, N-methyltryamine in fairly small amounts (about 0.02 percent) and traces of N-methyl-3,4-dimethoxy-B-phenethylamine, and N-methyl-4-B- phenethylamine. Aside from these alkaloids it also contains a flavone called retusin (3,3',4',7-tetramethoxy-5-hydroxyflavone). Although alkaloid content may very some at different seasons or stages of growth, from the scientific point of view the amounts present in this plant appear insufficient to pro- duce any psychopharmacological response.

SUNAMI:
This plant, ARIOCARPUS FISSURATUS, has been used in folkoric medicine of Mexico and southwestern USA. It is believed to be more potent than peyote and is used in the same manner as that cactus or made into an intoxicating drink. Among some tribes it is known as Chaute (a generic term for Ariocarp- us species), living rock, or dry whiskey. The latter name, however, is often used for peyote and other psychoactive cacti. There are two varieties of A. fissuratus: var. lloydii and var. fissuratus. Both have about the same phytochemical makeup. The plant contains mostly hordenine, less N-methyl- tyramine and some N-methyl-3,4-dimethoxy-B-phenethylamine. Two other species, A. kotschoubeyanus also known as Pata De Venado or Pezuna De Venado, and A. trigonus also contain these alkaloids.

DONANA:
This small cactus, CORYPHANTHA MACROMERIS, from northern Mexico has been found to contain macromerine, a phenethylamine drug reputed to have about 1/5 the potency of mescaline. It also contains normacromerine, N-formylnor- macromerin, tyramine, N-methyltramine, hordenine, N-methyl-3,4-dimethoxy-B- phenethylamine, metanephrine, and synephrine (a macromerine precursor). Other coryphantha species which contain macromerine with most of these other alkaloids include: C. pectinada, C. elephantideus, C. runyonii and C. corn- ifera var. echinus. Most of these alkaloids with the exception of macromerine have also been found in other varieties of C. conifera and in C. durangensis, C. ottonis, C. poselgeriana and C. ramillosa. Considering that there is usually no more than 0.1 percent macromerine in Donana and that a gram or more of this alkaloid may be needed to produce a psychotropic effect, one would have to consume more than a kilo of the dried cactus or 20 pounds of the fresh plant. Clearly this is not possible for most humans. If one wishes to experiment with the hallucinogenic properties of Donana, is is necessary first to make an extraction of the mixed alkaloids. Methods for this are given latter in this guide.

DOLICHOTHELE:
Several tribes occasionally use any one of several species of Dolichothele as a peyote-like sacrament. These include D. baumii, D. longimamma, D. melalenca, D. sphaerica. D. surculosa, and D. uberiforma. Recent investig- ations have revealed in these the presence of small amounts of the alkaloids N-methylphenethylamine, B-O-methylsynephrine, N-methyltryamine, synephrine, hordenine, and dolichotheline (N-isovalerylhistamine).

MISCELLANEOUS:
Several other cacti have been used by the Tarahumares as peyote substitutes. Among these are Obregonia denegrii, Aztekium ritterii, Astrophytum asterias, A. capricorne, A. myriostigma (Bishops cap), and Solisia pectinata. The Tarahumares also consume a cactus which they call Mulato (Mammillaria micro- meris) and claim that it prolongs life, gives speed to runners, and clarifies vison for mystical insights. Another cactus similarly employed is known as Rosapara (Epitheliantha micromeris) is believed by many botanists to be the same species as Mulato, but at a later vegetative stage. The large cactus Pachycereus pecten-aboriginum, known locally as Cawe, has occasionally been used as a narcotic.

What little studies have been carried out on these cacti have revealed the presence of alkaloids most of the other species we have discussed, but no mescaline or macromerine. Many of these alkaloids have some psychopharma- calogical properties, but nothing to compare with those two drugs. Further- more, the amounts of these alkaloids are usually so small as to be insignif- icant. For example, the species Obregonia denegrii contains tyramine 0.003 percent, hordenine 0.002 percent, and N-methyltyramin 0.0002 percent. These are all known sympathomimetics, but the percentages are far too minute to have any value. Several publications in recent years have mentioned the sacramental use of these cacti. As a result thousands of people have obtained these plants from cactus dealers and ingested them, usually with disappointing (and sometimes nauseating) results. Sadly many of these cacti are quite rare. If too many people destroy them experimentally, they may become a seriously endangered species. The most suitable cacti for a true psychedelic experience are peyote, which is for the most part illegal, and several species of Tri- chocereus (such as San Pedro), which are still legal.

SAN PEDRO:
This cactus has gained considerable fame in the past five years after numerous reports that it is hallucinogenic, contains mescaline, and is readily available from cactus nurseries. This plant known botanically as Trichocereus pachanoi, is native to the Andes of Peru and Equador. Unlike the small peyote cactus, San Pedro is large and multi-branched. In it's natural enviorment, it often grows to heights of 10 or 15 feet. It's mescaline content is less than that of peyote (0.3 - 1.2 percent), but because of it's great size and rapid growth, it may provide a more econom- ical source of mescaline than peyote. One plant may easily yield several pounds of pure mescaline upon extraction. San Pedro also contains tyramine, hordenine, 3-methoxytyramine, anhalaninine, anhalonidine, 3,4-dimethoxyphen- ethylamine, 3,4-dimethoxy-4-hydroxy-B-phenethylamine, and 3,5-dimethoxy-4- hydroxy-B-phenethylamine. Some of these are known sympathomimetics. Others have no apparent effects when ingested by themselves. It is possible, how- ever, that in combination with the mescaline and other active compounds they may have a synergistic influence upon one another and subtly alter the qual- itive aspects of the experience. It is also possible that any compounds in the plant which act a mild MAO inhibitors will render a person vulnerable to some of the above mentioned amines which would ordinarily be metabolized before they could take effect.

The effects of San Pedro are in many ways more pleasant than those of peyote. To begin with, it's taste is only slightly bitter and the initial nausea is not as likely to occur. When the full psychotropic experience takes hold it is less overwhelming, more tranquil and not nearly as physical as that from peyote.

San Pedro may be eaten fresh or dried and taken in any of the manners describ- ed for peyote. Cuttings of San Pedro sold in the USA are usually about three feet long by four inches diameter. A piece 4-8 inches long will usually bring about the desired effect. The skin and spines must be removed. The skin should not be thrown away, however. The green tissue close to the skin con- tains a high concentration of mescaline. Some people chew the skin until all the juices are extracted. If you don't what to do this, the skins can be boiled in water for several hours to make a potent tea. The woody core of the cactus cannot be eaten. One can eat around it like a corn cob. The core does not have much alkaloid content, but can be mashed and boiled as a tea for what little is there.

To dry San Pedro slice the cactus into disks (actually stars) 1/2 inch thick and dry thoroughly in the sun or in an oven at 250 degrees F. The spines must be removed either before drying or before chewing. Also one must be careful of the splinters from the woody core.

If a tea is made from fresh San Pedro, the cactus must be either sliced, chopped or crushed before boiling.

San Pedro is a hardy cactus and endures cold climates quite well. It grows at altiudes from sea level to 9000 feet high in the Andes where it is most freq- uently found on western slopes. The soil in this region is very rich in humus and various minerals. This helps in the production of mescaline and other alkaloids.

There are several cacti which look much like San Pedro and have even been mistaken for it by trained botanists. In 1960 when Turner and Heyman disc- overed that San Pedro contained mescaline they erroneously identified the plant as Opunita cylindtica. A few other South American species of Tricho- cereus also contain mescaline with related alkaloids. These include: T. BRIDGESII, T. MACROGONUS, T.TERSCHECKII, and T. WERDERMANNIANUS.

There is evidence that the ritualistic use of San Pedro dates back to 1000 BC. Even today it is used by Curanderos (medicine men) of northern Peru. They prepare a drink called CIMORA from it and take this in a ceremonial setting to diagnose the spiritual or subconscious basis of a patient's illness.

Cultivation of psychoactive cacti
Any cactus can be grown from either seed or cutting. Seed grown plants can take many years to develop to a usable size, but should ultimately provide strong, healthy stock from which cuttings may be taken. Plants have to grow through the lengthy seedling stage. A San Pedro plant started from seed may be no more than 1/2 inch high after it's first year and perhaps an inch high after it's second; It's diameter being 1/8-1/4 during this time. A cutting of San Pedro may be 2 feet high by 4 inches diameter when planted. After 6 months it might easily gain 4-6 inches in height, send forth one or two branches 6-8 inches long by 2 inches diameter, and have sprouted several branch buds which will do the same within the next six months. When these offshoots are 6 inches or more long they may be broken off and planted following the instructions below. Or they may be allowed another 6 months growth until they deepen from pale to dark-green to give them time to accum- ulate alkaloids and then consumed.

Live plants of any of the species mentioned in this guide - with the excep- tion perhaps of peyote - can be purchased from suppliers named at the end of this chapter. Freshly harvested peyote cuttings are frequently available on the underground market for 50 cents to one dollar per button. When select- ing peyote cuttings for planting choose ones which are firm and unbruised with at least 1/2 inch of taproot below the top. If the bottom of the tap- root is still delicate where it has been cut, the button should be placed bottoms up in partial shade for a day or two until the severed area has a dry corky texture. If this is not done, the plant will be prone to rot.

The best soil mix can be prepared from 3 parts coarse sand, 1 part loam and 1 part leaf mold. Bake this mixture in an oven at 400 degrees F for an hour to kill fungus, bacteria, weed seeds and insect eggs. After the soil mix has cooled it is ready to use. The taproot of the plant may be dipped in a rooting mixture, such as ROOTONE, before planting. This enhances root development and hinders decay. Place the bottom just deep enough so that the soil does not quite touch the green part of the plant. The soil should be kept slightly moist and evenly so. If you are planting a tall cactus like San Pedro, the cutting should be placed deeply enough in the soil that it will have sufficient support to stand. San Pedro type cacti can also be laid upon the ground and will send down roots from their sides while the buds grow upwards. San Pedro can grow well in almost any soil as long as there is decent drainage.

Cacti tend to grow mostly during spring and autumn, to send down roots in the summer, and to rest through winter. Although cactus cuttings may be planted anytime of the year they stand the best chance if planted in the late spring. They should be watered thoroughly once or twice a week depending upon how rapidly moisture is lost. The soil an inch below the surface should always contain some moisture. Watering can be cut back to less than half during the winter.

Increasing the potency of psychoactive cacti
There are several factors which influence production of mescaline and related alkaloids in cacti. Presence of a wide variety of trace minerals is import- ant. Occasional watering with Hoagland A-Z trace mineral concentrate provides these minerals. Combine 1 part concentrate with 9 parts water and water cacti with this once every two months.

Experiments conducted by Rosenberg, Mclaughlin and Paul at the University of of Michigan, Ann Arbor in 1966 demonstrated that dopamine is a precursor of mescaline in the peyote cactus. Tyramine and dopa were also found to be mescaline precursors, but not as immediate and efficient as dopamine. It appears that in the plant tyosine breaks down to become tyramine and dopa. These then recombine to form dopamine which is converted to nor-mescaline and finally to mescaline. One can take advantage to this sequence by inject- ing each peyote plant with dopamine 4 weeks prior to harvesting. Much of the dopamine will convert to mescaline during this time, giving a considerable increase in the alkaloid of the plant. Prepare a saturated solution of free base dopamine in a .05 N solution of hydrochloric acid and inject 1-2 cc into the root of each plant and the same amount into the green portion above the root. Let the needle penetrate to the center of the plant, inject slowly and allow the needle to remain in place a few seconds after injection. It is best to deprive the plant of water for 1-2 weeks before injection. This makes the plant tissues take up the injection fluids more readily. If dopamine is not available, a mixture of tyramine and dopa can be used instead 6 weeks before harvesting for comparable results. San Pedro and other mescaline- bearing cacti can be similarly treated for increased mescaline production. Inject at the base of the plant and again every 3-4 inches following a spiral pattern up the length of the plant. A series of booster injections can be given to any of these cacti every 6-8 weeks and once again 4 weeks before harvesting for greater mescaline accumulation.

It is also possible to increase the macromerine and nor-macromerine content of Donana cacti using tyramine or DL-norepinephrine as precursors. Injections should be given 20-25 days before harvesting. Series of injections can be given 45 days apart for higher alkaloid accumulation.

Dictionary of cactus alkaloids
Anhalidine: Tetrahydroisoquinoline alkaloid (2-methyl-6,7-dimeethoxy-8- hydroxy-1,2,3,4,-tetrahydroisoquinoline) Found in Lophophora and Pelecyphora.

B-O-methylsynephrine: Phenolic B-phenethylamine found in citrus trees and some cacti. No data on pharmacology, but similar compound B-O-methylepin- ephrine produces considerable CNS stimulation.

3-dimethyltrichocereine: B-phenethylamine alkaloid (N,N-dimethyl-3-hydroxy- 4,5-dimethoxy-B-phenethylamine). Found in Pelecyphora and some Trichocereus species.

Dolichotheline: Imidazole alkaloid properly known as N-isovalerylhistamine or 4(5)-[2-N-isovalerylaminoethyl]imidazole. Found only in Dolichothele and Gymnocactus species. Pharmacological action still unknown.

Homoveratrilamine: a dimethoxy form of the mescaline molecule (3,4-dimeth- oxy-B-phenethylamine). It has no activity by itself, but may alter the mescaline experience slightly when taken in combination. It is found in San Pedro cactus and in the urine of certain types of schizophrenics.

Hordenine: Phenolic B-phenethylamine found in barley roots and several cacti. Also known as anhaline (N,N-dimethyltyramine). Has mild sympatho- mimetic activity and antiseptic action.

Macromerine: Nonphenolic B-phenethylamine (N,N-dimethyl-3,4-dimethoxy-B- hydroxy-B-phenethylamine. Found only in Coryphantha species. Reputed to possess 1/5 the potency of mescaline.

Mescaline: Nonphenolic B-phenethylamine (3,4,5-trimethoxy-B-phenethylamine). main psychoactive component of Peyote, San Pedro, and several other tricho- cereus species. Also found in traces in Pelecyphorea.

Metanephrine: Weak sympathomimetic found in Coryphantha species.

3-methoxytyramine: Pheneolic B-Phenethylamine found in the plant kingdom for the first time in San Pedro cacti. Also found in the urine of persons with certain types of brain disorders and cancer of the nervous system.

N-methyl-3,4-dimethoxy-B-Phenethylamine: Found in Pelecyphora aselliformis, Coryphantha runyonii and Ariocarpus species, but not in peyote. Has slight activity in depletion of cardiac norepinephrine.

N-methylphenethylamine: Nonphenolic B-phenethylamine alkaloid recently found in the Dolichothele species. Also found in Acacia species and other plants. Goats and sheeps in Texas sometimes eat Acacia berlandia and suffer a condition known as limberleg or Guajillo wobbles. Pressor action of this alkaloid has been shown experimentally to occur with low toxicity. Phenealanine and meth- ionine are it's biosynthetic precursors.

N-methyltyramine: Phenolic B-phenethylamine found in some cacti, mutated barley roots and a few other plants. Probably an intermediate phytochemical step in the methylation of tyramine to form candicine. Has mild sympathomim- etic action and probable antibacterial properties.

Normacromerine: Nonphenolic B-phenethylamine (N-dimethyl-3,4-dimethoxy-B- hydroxy-B-phenethylamine) found in Coryphantha species. Shows less effect on rats than macromerine.

Pellotine: Tetrahydroisoquinoline alkaloid (1,2-dimethyl-6,7-dimethoxy-8- hydroxy-1,2,3,4-tetrahydroisoquinoline) found in Lophophora and pelecyphora.

Synephrine: Phenolic B-phenethylamine (N-methyl-4-hydroxy-B-phenethylamine) found in citrus plants, some cacti, and human urine. Well known sympathomim- etic agent. Probably an intermediary in phytosynthesis of macromerine.

Tyramine: Phenolic B-phenethylamine found in several cacti. Mild sympatho- mimetic with some possible antiseptic activity.
LSD-Generic name for the hallucinogen lysergic acid diethylamide-25. Discovered by Dr. Albert Hofmann in 1938, LSD is one of the most potent mind-altering chemicals known. A white, odorless powder usually taken orally, its effects are highly variable and begin within one hour and generally last 8-12 hours, gradually tapering off. It has been used experimentally in the treatment of alcoholics and psychiatric patients. (Where it showed some success.) It significantly alters perception, mood, and psychological processes, and can impair motor coordination and skills.

During the 1950s and early 1960s, LSD experimentation was legally conducted by psychiatrists and others in the health and mental health professions. Sometimes dramatic, unpleasant psychological reactions occur, including panic, great confusion, and anxiety. Strongly affected by set and setting.
Slang names
Acid, sugar.
Drug Slang Terms (NB: many of these refer to the carrier, ie, "Blotter" or "Sugar Cubes". Often the local names will refer to patterns printed on the blotter, eg, "Blue unicorn".):
Acid, 'Cid, Sid, Bart Simpsons, Barrels, Tabs, Blotter, Heavenly blue, "L", Liquid, Liquid A, Lucy in the sky with diamonds, Micro dots, Mind detergent, Orange cubes, Orange micro, Owsley, Hits, Paper acid, Sacrament, Sandoz, Sugar, Sugar lumps, Sunshine, Tabs, Ticket, Twenty-five, Wedding bells, Windowpane, etc.
Addiction potential:
Zero physical addiction potential. Not something that makes you want to do it again immediately.
Essentially zero psychological addiction potential.

Rarely people use it to escape in a negative way or as part of "poly drug abuse" behavior or pattern of behavior. Usually in this case other drugs are causing more harm, and the fundamental problem is a personal difficulty; the escapism/distraction is a symptom.
Bad trips:
The most common adverse reaction is a temporary (less than 24 hours) episode of panic --the "bad trip". Symptoms include frightening illusions/ hallucinations (usually visual and/or auditory); overwhelming anxiety to the point of panic; aggression with possible violent acting-out behavior; depression with suicidal ideations, gestures, or attempts; confusion; and fearfulness to the point of paranoid delusions.

A person on LSD who becomes depressed, agitated, or confused may experience these feelings in an overwhelming manner that grows on itself. The best solution is to remove disturbing influences, get to a safe, comforting environment, and reassure the tripper that things are alright. It may comfort those who fear that they are losing their minds to be reminded that it will end in several hours.

Authorities are fond of administering injections of anti-psychotic drugs. Recovery in the presence of authorities, in hospitals or police stations, is not pleasant. Sedatives or tranquilizers such as Valium may help reduce panic and anxiety, but the best solution is calm talking.

Remember that odd bodily sensations are normal and not harmful. "The distinction between psycholytic and psychedelic doses of LSD is used in many scientific publications but seems to be ignored by popularizers who either preach the "LSD utopia" or warn of the "decline of the West."
A psycholitic dose, generally 75 or 100 - or at most 200 - micrograms, causes a rush of thoughts, a lot of free association, some visualization (hallucination) and abreaction (memories so vivid that one seems to relive the experience).
A psychedelic dose, around 500 micrograms, produces total but temporary breakdown of usual ways of perceiving self and world and (usually) some form of "peak experience" or mystic transcendence of ego. "Bad trips" usually occur only on psychedelic doses."

Reactions that are prolonged (days to months) and/or require hospitalization are often referred to as "LSD psychosis," and include a heterogeneous population and group of symptoms. Although there are no hard and fast rules, some trends have been noted in these patients. There is a tendency for people with poorer pre morbid adjustment, a history of psychiatric illness and/or treatment, a greater number of exposure to psychedelic drugs (and correlatively, a great average total cumulative dosage taken over time), drug-taking in an unsupervised setting, a history of poly drug abuse, and self-therapeutic and/or peer-pressure-submission motive for drug use, to suffer these consequences.
myths
1. LSD does not form "crystals" that reside in the body to be "dislodged" later, causing flashbacks.

LSD is a crystalline solid (though it is unlikely that one would ever have enough to be visible to the naked eye) but it is easily water soluble, thus cannot form bodily deposits. Furthermore, it is metabolized and excreted in hours. The bogus "loosened crystal" description in not necessary to explain flashbacks, which are psychological phenomena (see FLASHBACKS).

2. LSD does not cause chromosome damage.

In Science 30 April 1972, Volume 172 Number 3982 p. 431-440 there was an article by Norman I. Dishotsky, William D. Loughman, Robert E. Mogar and Wendell R. Lipscomb titled "LSD and Genetic Damage - Is LSD chromosome damaging, carcinogenic, mutagenic, or teratogenic?". They reviewed 68 studies and case reports published 1967-1972, concluding "From our own work and from a review of literature, we believe that pure LSD ingested in moderate doses does not damage chromosomes in vivo, does not cause detectable genetic damage, and is not a teratogen or carcinogen in man."

Well, there's the study by Sidney Cohen which was cited here recently, Journal of Nervous and Mental Disease, 130, 1960. The following is from Jay Stevens' Storming Heaven: "Cohen surveyed a sample of five thousand individuals who had taken LSD twenty-five thousand times. He found and average of 1.8 psychotic episodes per thousand ingestions, 1.2 attempted suicides, and 0.4 completed suicides. 'Considering the enormous scope of the psychic responses it induces,' he concluded, 'LSD is an astonishingly safe drug.'"
Dangers
Purely psychological hazards, not harmful to body. May release latent psychosis or exacerbate depression, leading to irrational behavior. There is also a danger of foolish or incautious behavior, e.g, misjudging distances or thinking one can fly. Physical overdose is not a hazard, though one may easily ingest more than one may be able to handle psychologically.
Flashbacks
Quoted without permission from 'Licit and Illicit Drugs,' written by Edward M. Brecher and the editors of Consumer Reports. ISBN: 0-316-15340-0

A simple explanation of LSD flashbacks, and of their changed character after 1967, is available. According to this theory, almost everybody suffers flashbacks with or without LSD. Any intense emotional experience--the death of a loved one, the moment of discovery that one is in love, the moment of an automobile smashup or of a narrow escape from a smashup--may subsequently and unexpectedly return vividly to consciousness weeks or months later. Since the LSD trip is often an intense emotional experience, it is hardly surprising that it may similarly "flash back."
A typical minor and pleasant flashback is the following:
... Frequently afterward there is a momentary "opening" ("flash" would be too spastic a word) when for maybe a couple of seconds an area one is looking at casually, and indeed unthinkingly, suddenly takes on the intense vividness, composition, and significance of things seen while in the psychedelic condition. This "scene" is nearly always a small field of vision -- sometimes a patch of grass, a spray of twigs, even a piece of newspaper in the street or the remains of a meal on a plate
(Cohen 1970[1965], pp. 114-115)
Here are two more troublesome examples:
For about a week I couldn't walk through the lobby of A-entry at the dorm without getting really scared, because of the goblin I saw there when I was tripping.
(Pope 1971, p. 93)

A man in his late twenties came to the admitting office in a state of panic. Although he had not taken any drug in approximately 2 moths he was beginning to re-experience some of the illusory phenomena, perceptual distortions, and the feeling of union with the things around him that had previously occurred only under the influence of LSD. In addition, his wife had told him that he was beginning to "talk crazy," and he had become frightened ... He was concerned lest LSD have some permanent effect on him. He wished reassurance so that he could take it again. His symptoms have subsided but tend to reappear in anxiety-provoking situations.
(Frosch et al. 1965, p. 1237)

Flashbacks are most likely to occur under emotional stress or at a time of altered ego functioning; they are often induced by conditions like fatigue, drunkenness, marihuana intoxication, and even meditative states. Falling asleep is one of those times of consciousness change and diminished ego control; an increase in the hypnagogic imagery common at the edge of sleep often follows psychedelic drug use and can be regarded as a kind of flashback.

Dreams too may take on the vividness, intensity, and perceptual peculiarities of drug trips; this spontaneous recurrence of psychedelic experience in sleep (often very pleasant) has been called the high dream (Tart 1972). Marihuana smoking is probably the most common single source of flashbacks. Many people become more sensitive to the psychedelic qualities of marihuana after using more powerful drugs, and some have flashbacks only when smoking marihuana (Weil 1970). In one study frequency of marihuana use was found to be the only factor related to drugs that was correlated with number of psychedelic flashbacks (Stanton et al. 1976).

How common flashbacks are said to be depends on how they are defined. By the broad definition we have been using, they occur very often; probably a quarter or more of all psychedelic drug users have experienced them. A questionnaire survey of 2,256 soldiers (Stanton and Bardoni 1972), leaving the definition to the respondents, revealed that 23 percent of the men who used LSD had flashbacks. In a 1972 survey of 235 LSD users, Murray P. Naditch and Sheridan Fenwick found that 28 percent had flashbacks. Eleven percent of this group (seven men in all) called them very frightening, 32 percent called them somewhat frightening, 36 percent called them pleasant, and 21 percent called them very pleasant. Sixty-four percent said that their flashbacks did not disrupt their lives in any way; 16 percent (4 percent of the whole LSD-using group) had sought psychiatric help for them (Naditch and Fenwick 1977). In a study of 247 subjects who had taken LSD in psychotherapy, William H. McGlothlin and David O. Arnold found 36 cases of flashbacks, only one of which was seriously disturbing (McGlothlin and Arnold 1971). McGlothlin, defining flashbacks narrowly for clinical purposes as "repeated intrusions of frightening images in spite of volitional efforts to avoid them" (McGlothlin 1974b, p. 291), estimates that 5 percent of habitual psychedelic users have experienced them.

Insomnia
Insomnia occurs frequently after the trip. A mild, over-the-counter sleeping aid can help, and these antihistamines do not produce adverse interactions. Also, some people like to consume a small amount of alcoholic beverage to "smooth the jitters". The usual precautions about sleeping aids if alcohol has been consumed apply of course.
Tolerance
Acquired rapidly, within 3 days. Tolerance dissipates equally rapidly, without withdrawal, craving, or symptoms of addiction. Cross-tolerance can and is developed between other indole hallucinogens, eg, DMT, LSD and Psilocybin.
Related compounds
Related compounds are the indole hallucinogens including DMT (dimethyl-tryptamine), DET (diethyl-), etc.; psilocybin; lysergic acid. DMT is very fast acting, lasting less than an hour. Psilocybin, found in hallucinogenic (aka magic or mexican) mushrooms, has effects similar to LSD but they work for approximately half the duration.

While LSD is semi-synthetic, DMT and psilocybin are found in nature.
Drug testing
No risk. Its not looked for, hard to find, and transient.
Morning glory seeds[/u:2415e9cf3

The following 1 user thanked connor122 for this useful post:

kitcj3000 (05-31-2010)
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i-Flux
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dont do drugs kids! 8)

& stay in school
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Other drugs
Cocaine (& crack)-Cocaine
Cocaine is a powerful central nervous system (CNS) stimulant that heightens alertness, inhibits appetite and the need for sleep, and provides intense feelings of pleasure. It is prepared from the leaf of the Erythroxylon coca bush, which grows primarily in Peru and Bolivia.

Pure cocaine was first extracted and identified by the German chemist Albert Niemann in the mid-19th century, and was introduced as a tonic/elixir in patent medicines to treat a wide variety of real or imagined illnesses. Later, it was used as a local anesthetic for eye, ear, and throat surgery and continues today to have limited employment in surgery. Currently, it has no other clinical application, having been largely replaced by synthetic local anesthetics such as lidocaine.

Because of its potent euphoric and energizing effects, many people in the late 19th century took cocaine, even though some physicians recognized that users quickly became dependent. In the 1880s, the psychiatrist Sigmund Freud created a sensation with a series of papers praising cocaine's potential to cure depression, alcoholism, and morphine addiction.

Skepticism soon replaced this excitement, however, when documented reports of fatal cocaine poisoning, alarming mental disturbances, and cocaine addiction began to circulate.

According to information collected in 1902, 92% of all cocaine sold in major cities in the United States was in the form of an ingredient in tonics and potions available from local pharmacies.

In 1911, the Canadian government legally restricted cocaine use, and its popularity waned. The 1920s and '30s saw a marked decline in its use, especially after amphetamines became easily available. Cocaine's return to popularity, beginning in the late 1960s, coincided with the decreased use of amphetamines.

Appearance
Cocaine is generally sold on the street as a hydrochloride salt - a fine, white crystalline powder known as coke, C, snow, flake, or blow. Street dealers dilute it with inert (non-psychoactive) but similar-looking substances such as cornstarch, talcum powder, and sugar, or with active drugs such as procaine and benzocaine (used as local anesthetics), or other CNS stimulants such as amphetamines. Nevertheless, illicit cocaine has actually become purer over the years; according to RCMP figures, in 1988 its purity averaged about 75%.

Cocaine in powder form is usually "snorted" into the nostrils, although it may also be rubbed onto the mucous lining of the mouth, rectum, or vagina. To experience cocaine's effects more quickly, and to heighten their intensity, users sometimes inject it.

Cocaine hydrochloride can be chemically altered to remove other substances. The process, called "freebasing," is potentially dangerous because the solvents used are highly flammable. The pure form of cocaine that results ("free base") is smoked rather than snorted. The drug commonly called "crack" is a crude form of free base that has become popular in recent years.
Effects
The effects of any drug depend on several factors:

* the amount taken at one time
* the user's past drug experience
* the manner in which the drug is taken
* the circumstances under which the drug is taken (the place, the user's psychological and emotional stability the presence of other people, the simultaneous use of alcohol or other drugs, etc.).

Cocaine's short-term effects appear soon after a single dose and disappear within a few minutes or hours. Taken in small amounts (up to 100 mg), cocaine usually makes the user feel euphoric, energetic, talkative, and mentally alert - especially to the sensations of sight, sound, and touch. It can also temporarily dispel the need for food and sleep. Paradoxically, it can make some people feel contemplative, anxious, or even panic-stricken. Some people find that the drug helps them perform simple physical and intellectual tasks more quickly; others experience just the opposite effect.

Physical symptoms include accelerated heartbeat and breathing, and higher blood pressure and body temperature.

Large amounts (several hundred milligrams or more) intensify users' "high," but may also lead to bizarre, erratic, and violent behavior. These users may experience tremors, vertigo, muscle twitches, paranoia, or, with repeated doses, a toxic reaction closely resembling amphetamine poisoning.

Physical symptoms may include chest pain, nausea, blurred vision, fever, muscle spasms, convulsions, and coma. Death from a cocaine overdose can occur from convulsions, heart failure, or the depression of vital brain centres controlling respiration.

With repeated administration over time, users experience the drug's long-term effects. Euphoria is gradually displaced by restlessness, extreme excitability, insomnia, and paranoia - and eventually hallucinations and delusions. These conditions, clinically identical to amphetamine psychosis and very similar to paranoid schizophrenia, disappear rapidly in most cases after cocaine use is ended.

While many of the physical effects of heavy continuous use are essentially the same as those of short-term use, the heavy user may also suffer from mood swings, paranoia, loss of interest in sex, weight loss, and insomnia.

Chronic cocaine snorting often causes stuffiness, runny nose, eczema around the nostrils, and a perforated nasal septum. Users who inject the drug risk not only overdosing but also infections from unsterile needles and hepatitis or AIDS (acquired immune deficiency syndrome) from needles shared with others. Severe respiratory tract irritation has been noted in some heavy users of cocaine free base.

Tolerance and dependence
Tolerance to any drug exists when higher doses are necessary to achieve the same effects once reached with lower doses. But scientists have not observed tolerance to cocaine's stimulant effect: users may keep taking the original amount over extended periods and still experience the same euphoria. Yet some users frequently increase their dose to intensify and prolong the effects. Amounts up to 10 g (10,000 mg) have been reported.

Some users, however, report that they become more sensitive to cocaine's anesthetic and convulsant effects even without increasing the amount. This theory of increased sensitivity has been put forward to explain some deaths that have occurred after apparently low doses.

Psychological dependence exists when a drug is so central to a person's thoughts, emotions, and activities that it becomes a craving or compulsion. Among heavy cocaine users, an intense psychological dependence can occur; they suffer severe depression if the drug is unavailable, which lifts only when they take it again.

Experiments with animals suggest that cocaine is perhaps the most powerful drug of all in producing psychological dependence. Rats and monkeys made dependent on cocaine will always strive hard to get more.

At present, researchers do not agree on what constitutes physical dependence on cocaine. When regular heavy users stop taking the drug, however, they experience what they term the "crash" shortly afterwards.

Overall, during abstinence, many users complain of sleep and eating disorders, depression, and anxiety, and the craving for cocaine often compels them to take it again. Treatment of the dependent cocaine user is therefore difficult, and the relapse rate is high. Nevertheless, some heavy users have been able to quit on their own
Heroin (& other opiates)-Opium, codeine, morphine, heroin
The opioids include both natural opiates - that is, drugs from the opium poppy - and opiate-related synthetic drugs, such as meperidine and methadone.

The opiates are found in a gummy substance extracted from the seed pod of the Asian poppy, Papaver somniferum. Opium is produced from this substance, and codeine and morphine are derived from opium. Other drugs, such as heroin, are processed from morphine or codeine.

Opiates have been used both medically and non-medically for centuries. A tincture of opium called laudanum has been widely used since the 16th century as a remedy for "nerves" or to stop coughing and diarrhea.

By the early 19th century, morphine had been extracted in a pure form suitable for solution. With the introduction of the hypodermic needle in the mid-19th century, injection of the solution became the common method of administration.

Heroin (diacetylmorphine) was introduced in 1898 and was heralded as a remedy for morphine addiction. Although heroin proved to be a more potent pain killer (analgesic) and cough suppressant than morphine, it was also more likely to produce dependence.

Of the 20 alkaloids contained in opium, only codeine and morphine are still in widespread clinical use today. In this century, many synthetic drugs have been developed with essentially the same effects as the natural opium alkaloids.

Opiate- Opium, codeine, morphine, heroin
The opioids include both natural opiates - that is, drugs from the opium poppy - and opiate-related synthetic drugs, such as meperidine and methadone.

The opiates are found in a gummy substance extracted from the seed pod of the Asian poppy, Papaver somniferum. Opium is produced from this substance, and codeine and morphine are derived from opium. Other drugs, such as heroin, are processed from morphine or codeine.

Opiates have been used both medically and non-medically for centuries. A tincture of opium called laudanum has been widely used since the 16th century as a remedy for "nerves" or to stop coughing and diarrhea.

By the early 19th century, morphine had been extracted in a pure form suitable for solution. With the introduction of the hypodermic needle in the mid-19th century, injection of the solution became the common method of administration.

Heroin (diacetylmorphine) was introduced in 1898 and was heralded as a remedy for morphine addiction. Although heroin proved to be a more potent pain killer (analgesic) and cough suppressant than morphine, it was also more likely to produce dependence.

Of the 20 alkaloids contained in opium, only codeine and morphine are still in widespread clinical use today. In this century, many synthetic drugs have been developed with essentially the same effects as the natural opium alkaloids.

Opiate-related synthetic drugs, such as meperidine (Demerol) and methadone, were first developed to provide an analgesic that would not produce drug dependence. Unfortunately, all opioids (including naturally occurring opiate derivatives and synthetic opiate-related drugs), while effective as analgesics, can also produce dependence. (Note that where a drug name is capitalized, it is a registered trade name of the manufacturer.)

Modern research has led, however, to the development of other families of drugs. The narcotic antagonists (e.g. naloxone hydrochloride) - one of these groups - are used not as painkillers but to reverse the effects of opiate overdose.

Another group of drugs possesses both morphine-like and naloxone-like properties (e.g. pentazocine, or Talwin) and are sometimes used for pain relief because they are less likely to be abused and to cause addiction. Nevertheless, abuse of pentazocine in combination with the antihistamine tripelennamine (Pyribenzamine) was widely reported in the 1980s, particularly in several large cities in the United States. This combination became known on the street as "Ts and blues." The reformulation of Talwin, however, with the narcotic antagonist naloxone has reportedly reduced the incidence of Ts and blues use.

Appearance
Opium appears either as dark brown chunks or in powder form, and is generally eaten or smoked. Heroin usually appears as a white or brownish powder, which is dissolved in water for injection. Most street preparations of heroin contain only a small percentage of the drug, as they are diluted with sugar, quinine, or other drugs and substances. Other opiate analgesics appear in a variety of forms, such as capsules, tablets, syrups, elixirs, solutions, and suppositories. Street users usually inject opiate solutions under the skin ("skin popping") or directly into a vein or muscle, but the drugs may also be "snorted" into the nose or taken orally or rectally.
Effects
The effects of any drug depend on several factors:

* the amount taken at one time
* the user's past drug experience
* the manner in which the drug is taken
* the circumstances under which the drug is taken (the place, the user's psychological and emotional stability, the presence of other people, simultaneous use of alcohol or other drugs, etc.).

Short-term effects appear soon after a single dose and disappear in a few hours or days. Opioids briefly stimulate the higher centres of the brain but then depress activity of the central nervous system. Immediately after injection of an opioid into a vein, the user feels a surge of pleasure or a "rush." This gives way to a state of gratification; hunger, pain, and sexual urges rarely intrude.

The dose required to produce this effect may at first cause restlessness, nausea, and vomiting. With moderately high doses, however, the body feels warm, the extremities heavy, and the mouth dry. Soon, the user goes "on the nod," an alternately wakeful and drowsy state during which the world is forgotten.

As the dose is increased, breathing becomes gradually slower. With very large doses, the user cannot be roused; the pupils contract to pinpoints; the skin is cold, moist, and bluish; and profound respiratory depression resulting in death may occur.

Overdose is a particular risk on the street, where the amount of drug contained in a "hit" cannot be accurately gauged. In a treatment setting, the effects of a usual dose of morphine last three to four hours. Although pain may still be felt, the reaction to it is reduced, and the patient feels content because of the emotional detachment induced by the drug.

Long-term effects appear after repeated use over a long period. Chronic opiate users may develop endocarditis, an infection of the heart lining and valves as a result of unsterile injection techniques.

Drug users who share needles are also at a high risk of acquiring AIDS (acquired immune deficiency syndrome) and HIV infection (human immunodeficiency virus). Unsterile injection techniques can also cause abscesses, cellulitis, liver disease, and even brain damage. Among users with a long history of subcutaneous injection, tetanus is common. Pulmonary complications, including various types of pneumonia, may also result from the unhealthy lifestyle of the user, as well as from the depressant effect of opiates on respiration.

Tolerance and Dependence
With regular use, tolerance develops to many of the desired effects of the opioids. This means the user must use more of the drug to achieve the same intensity of effect.

Chronic users may also become psychologically and physically dependent on opioids.

Psychological dependence exists when a drug is so central to a person's thoughts, emotions, and activities that the need to continue its use becomes a craving or compulsion.

With physical dependence, the body has adapted to the presence of the drug, and withdrawal symptoms occur if use of the drug is reduced or stopped abruptly. Some users take heroin on an occasional basis, thus avoiding physical dependence.

Withdrawal from opioids, which in regular users may occur as early as a few hours after the last administration, produces uneasiness, yawning, tears, diarrhea, abdominal cramps, goose bumps, and runny nose. These symptoms are accompanied by a craving for the drug.

Major withdrawal symptoms peak between 48 and 72 hours after the last dose and subside after a week. Some bodily functions, however, do not return to normal levels for as long as six months. Sudden withdrawal by heavily dependent users who are in poor health has occasionally been fatal. Opioid withdrawal, however, is much less dangerous to life than alcohol and barbiturate withdrawal

Opioids and pregnancy
Opioid-dependent women are likely to experience complications during pregnancy and childbirth. Among their most common medical problems are anemia, cardiac disease, diabetes, pneumonia, and hepatitis. They also have an abnormally high rate of spontaneous abortion, breech delivery, caesarian section, and premature birth. Opioid withdrawal has also been linked to a high incidence of stillbirths.

Infants born to heroin-dependent mothers are smaller than average and frequently show evidence of acute infection. Most exhibit withdrawal symptoms of varying degrees and duration. The mortality rate among these infants is higher than normal.
Amphetamine (speed, pep)- Amphetamines
Amphetamines and amphetamine-related drugs are central nervous system stimulants whose actions resemble those of adrenaline, one of the body's natural hormones.

The most important of these stimulants are the original drug, amphetamine, and its close chemical relations, methamphetamine and dextroamphetamine. Only the latter, under the trade name Dexedrine, is legally manufactured today. Everything else is synthesized in illicit "basement" laboratories.

Amphetamine was first introduced in the 1930s as a remedy for nasal congestion. Later, all three drugs were found to be effective in treating such other conditions as hyperactivity in children and narcolepsy (uncontrollable sleeping fits). Although they were also prescribed to control obesity and depression, their use for these disorders has been discontinued because patients became quickly and seriously dependent.

The amphetamines have long been taken for their stimulant and euphoric effects. When they were easily available, truck drivers, students, and athletes were among those who used them extensively to prolong their normal periods of wakefulness and endurance.

Among street drug users, injectable methamphetamine, usually called "speed," has been the most popular of this group of drugs because the "high" is more rapid and intense than when the drug is taken orally. There are reports of a smokable form of methamphetamine, known on the street as "ice."

Other street names for these drugs are bennies, glass, crystal, crank, pep pills, and uppers.

Amphetamine misuse has declined dramatically since the near epidemic between 1950 and 1970. At the same time, however, there has been a marked increase in the use of such other stimulants as cocaine. As well, drugs related to amphetamine - such as MDA, PMA, TMA, and STP - have appeared on the street.

Appearance:
Illicit amphetamine appears as crystals, chunks, and fine to coarse powders, off-white to yellow in color, and supplied loose (in plastic or foil bags) or in capsules or tablets of various sizes and colors. The drug may be sniffed, smoked, injected, or taken orally in tablet or capsule form.
Effects
The effects of any drug depend on several factors:

* the amount taken at one time
* the user's past drug experience
* the manner in which the drug is taken
* the circumstances under which the drug is taken (the place, the user's psychological and emotional stability, the presence of other people, the simultaneous use of alcohol or other drugs, etc.).

Amphetamines, like adrenaline, affect not only the brain but also the heart, lungs, and many other organs. Short-term effects appear soon after a single dose and disappear within a few hours or days.

At low doses, such as those prescribed medically, physical effects include loss of appetite, rapid breathing and heartbeat, high blood pressure, and dilated pupils. Larger doses may produce fever, sweating, headache, blurred vision, and dizziness. And very high doses may cause flushing, pallor, very rapid or irregular heartbeat, tremors, loss of coordination, and collapse. Deaths have been reported as a direct result of amphetamine use. Some have occurred as a consequence of burst blood vessels in the brain, heart failure, or very high fever. The psychological effects of short-term use include a feeling of well-being and great alertness and energy. With increased doses, users may become talkative, restless, and excited, and may feel a sense of power and superiority. They may also behave in a bizarre, repetitive fashion. Many become hostile and aggressive. Paradoxically, in children these drugs frequently produce a calming effect and were often prescribed for hyperactivity.

Long-term effects appear soon after repeated use over a long period. With prolonged amphetamine use, the short-term effects are exaggerated. Because amphetamines specifically suppress appetite, chronic heavy users generally fail to eat properly and thus develop various illnesses related to vitamin deficiencies and malnutrition.

Users may also be more prone to illness because they are generally run down, lack sleep, and live in an unhealthy environment. Chronic heavy users may also develop amphetamine psychosis - a mental disturbance very similar to paranoid schizophrenia. The psychosis condition is an exaggeration of the short-term effects of high doses; the symptoms usually disappear within a few days or weeks after drug use is stopped.

Heavy users of amphetamines may be prone to sudden, violent, and irrational acts. These result from drug-induced self-centredness, distortions of perception, and delusions that other people are threatening or persecuting them. The deviant lifestyle of many users may increase the likelihood of such behavior.

In one Canadian study, violence (either accidental, self -inflicted, or perpetrated by others) was the leading cause of amphetamine-related deaths. Violent death was at least four times as common among regular users of amphetamines as among non-users of the same age and sex.

As a way of coping with undesired amphetamine effects, users may turn to other dependence-producing drugs. Depressant drugs, particularly barbiturates, alcohol, and opiates, may be used to aid sleep or compensate for overdose. Thus users risk, in turn, addiction to these drugs as well.

Infections from unsterile needles are not unusual among users who inject the drug. Some infections are passed from user to user via shared needles. Hepatitis, for example, is common among speed users who regularly employ a needle; AIDS (acquired immune deficiency syndrome) may spread in the same way.

Amphetamine products often contain substances that do not easily dissolve in water. When users inject the drug, these particles can pass into the body and block small blood vessels or weaken the blood vessel walls. Kidney damage, lung problems, strokes, or other tissue injury may result.

Tolerance and dependence
Regular use of amphetamines induces tolerance to some effects, which means that more and more of the drug is required to produce the desired effects. Tolerance does not develop to all effects at the same rate, however; indeed, there may be increased sensitivity to some of them.

Chronic users may also become psychologically dependent on amphetamines. Psychological dependence exists when a drug is so central to a person's thoughts, emotions, and activities that the need to continue its use becomes a craving or compulsion. Experiments have shown that animals, when given a free choice, will readily operate pumps that inject them with cocaine or amphetamine. Animals dependent on amphetamines will work hard to get more of the drug.

Physical dependence occurs when the body has adapted to the presence of the drug, and withdrawal symptoms occur if its use is stopped abruptly. The most common symptoms of withdrawal among heavy amphetamine users are fatigue, long but troubled sleep, irritability, intense hunger, and moderate to severe depression, which may lead to suicidal behavior. Fits of violence may also occur. These disturbances can be temporarily reversed if the drug is taken again.

Amphetamines and pregnancy
Little research has been done in humans into the effects of amphetamine use on pregnancy and fetal growth. Experiments with animals suggest, however, that use during pregnancy may produce adverse behavioral effects, such as hyperexcitability, in offspring. And among humans, several cases have been documented of withdrawal symptoms among newborn infants of mothers using amphetamines.

Other Stimulants
In the past few years, there has been increasing use of nasal decongestants for their relatively mild stimulant properties. Various combinations of ephedrine, phenylpropanolamine (PPA), and caffeine are often misrepresented as "speed" or are sold in capsules that resemble those of legally manufactured amphetamines; these are called "look-alike" stimulants. Taken in doses high enough to stimulate the central nervous system, these drugs (especially when used in combinations) can produce such side effects as high blood pressure, irregular heartbeat, and agitation. Deaths due to stroke have been reported following massive doses of look-alike combinations or of a related decongestant, propylhexadrine
PCP- PCP
PCP (phencyclidine) was first used in the 1950s as an anesthetic for surgery. But because it produced such highly undesirable side effects as convulsions during operations and post-operative hallucinations, its use was quickly discontinued.

In the 1960s it was marketed again, this time to veterinarians strictly as an animal anesthetic and tranquillizer. It was at this time that San Francisco's drug subculture discovered the drug and nicknamed it the "peace pill" - possibly hence the name PCP. (Scientifically, PCP is an abbreviation for the drug's chemical name, phenylcyclohexylpiperidine.) On the street it also became known as angel dust, crystal, hog, or horse tranquillizer.

PCP is no longer used by veterinarians and is produced today only in illicit laboratories. A synthetic drug (chemically unrelated to LSD or mescaline), PCP is a white crystalline powder, readily soluble in water or alcohol. On the street, it is sold in the form of pills, capsules, or powder.

The drug can be taken orally - as a liquid, tablet, or capsule. It is also "snorted" (sniffed), or smoked in "joints" mixed with tobacco, marijuana, or dried parsley. It can also be taken intravenously. If it is injected, unsterile needles may cause infections. Those sharing needles with other users risk hepatitis or AIDS (acquired immune deficiency syndrome).

PCP is difficult to classify accurately, since different doses produce different effects - such as those derived from stimulants, hallucinogens, anesthetics, or analgesics (painkillers). Not all people react the same way to the drug, even after taking the same amount.

Effects
The effects of any drug depend on several factors:

* the amount taken at one time
* the user's past drug experience
* the manner in which the drug is taken
* the circumstances under which the drug is taken (the place, the user's emotions and activities, the presence of other people, the simultaneous use of alcohol or other drugs, etc.).

A particular concern with PCP is the frequency with which dealers falsely present it as some other drug, such as mescaline or peyote. Thus buyers, expecting the relatively mild effects of these drugs, suddenly experience the stronger and unpredictable effects of PCP - or of PCP combined with another drug such as LSD.

Moreover, since the content of PCP varies widely from one street product to another, the intensity and duration of its effects cannot be predetermined. In street samples analysed at the Addiction Research Foundation, PCP content ranged from 1.3 to 81 mg per unit dose.

Short-term effects appear soon after taking a single dose of PCP, and disappear within a few hours or days.

At low doses (e.g. 5 mg or less), the physical effects of PCP may include: shallow and rapid breathing, increased blood pressure and heart rate, a marked rise in temperature, profuse sweating, and a numbness in arms and legs. At higher doses (e.g. 10 mg or more), there is a rapid drop in blood pressure, heart rate, and respiration, which in turn is accompanied by nausea, vomiting, blurred vision, dizziness, and decreased awareness of pain. Muscles contract so intensely they cause jerky, uncoordinated movements and bizarre postures. Heavy doses of the drug can cause convulsions and coma.

PCP's effects on the brain inhibit the user's ability to concentrate, to think logically, and to articulate. Dramatic changes in perception, thought, and mood occur. While some users experience mild to intense euphoria, others feel threatened and because of fear, anxiety, or panic - can behave violently. The drug may also release hidden emotional or mental problems.

Among the effects of higher doses - which mimic certain symptoms of schizophrenia and can take two weeks to disappear - are delusions, hallucinations (mainly auditory), and a sensation of distance from one's environment. Most regular users admit having had at least one "bad trip." But the hope of achieving the extraordinary "high" that PCP can bring is powerful enough to keep them taking the drug.

Some deaths have been directly linked to PCP overdoses (with amounts between 150 and 200 mg); others have been linked to the drug's psychological impact - causing accidental drownings, suicides, homicides, and car crashes.

Little is known about PCP's long-term effects, which appear after repeated use over a lengthy period. Some users suffer unpleasant "flashbacks" similar to those experienced by LSD users. These are unpredictable, spontaneous recurrences of the original PCP trip without the user's having taken the drug again. Flashbacks can occur weeks, months, or even up to a year after the last encounter with the drug. Typically, they last only a few minutes, and are usually visual images ranging from formless colors to frightening hallucinations.

After prolonged use, persistent speech problems, loss of memory (particularly recent memory), and severe, long-lasting anxiety, depression, and social withdrawal have also been noticed in users.

Tolerance and dependence
Little research has been done on whether PCP results in tolerance and dependence. Since regular users seem to need to increase their intake of PCP in order to maintain the "high," however, researchers infer that tolerance does occur.

Psychological dependence is suggested by the compulsive daily consumption of, and craving for, the drug by some users.

There is no physical dependence on PCP after continuous use, for there are no withdrawal symptoms after the drug is discontinued.
Barbiturates-Barbiturates
Barbiturates are powerful depressants that slow down the central nervous system (CNS). Classified as sedative/hypnotics, they include amobarbital (e.g. Amytal), pen obarbital (e.g. Nembutal), phenobarbital (e.g. Luminal), secobarbital (e.g. Seconal), and the combination amobarbital-secobarbital (e.g. Tuinal). (Note that where a drug name is capitalized, it is a registered trade name of the manufacturer.)

What is discussed in this paper are most of the sedative/hypnotics that are not benzodiazepines. (For a discussion of benzodiazepines, see Facts About Tranquillizers.)

Barbiturates and other sedative/hypnotics are medically prescribed to treat sleeplessness, anxiety, and tension, and to help prevent or mitigate epileptic seizures. Certain barbiturates are also used to induce anesthesia for short surgical procedures or at the beginning of longer ones.

Because of the risks associated with barbiturate abuse, and because new and safer drugs such as the benzodiazepines are now available, barbiturates are less frequently prescribed than in the past. Nonetheless, they are still available both on prescription and illegally.

Besides having therapeutic uses, barbiturates are often used for their pleasurably intoxicating effects. Some people take them in addition to alcohol, or as a substitute. Heavy users of other drugs sometimes turn to them if their usual drugs are not available, or to counteract the effects of large doses of stimulants such as amphetamines or cocaine.

Barbiturates are known generally on the street as "downers" or "barbs." Many are named for the colors of their brand name versions - blues or blue heavens (Amytal), yellow jackets (Nembutal), red birds or red devils (Seconal). and rainbows or reds and blues (Tuinal).

Effects
The effects of any drug depend on several factors:

* the amount taken at one time
* the user's past drug experience
* the manner in which the drug is taken
* the circumstances under which the drug is taken (the place, the user's psychological and emotional stability, the presence of other people, the simultaneous use of alcohol or other drugs, etc.).

Short-term effects are those that appear rapidly after a single dose and disappear within a few hours or days. With barbiturates, a small dose (e.g. 50 mg or less) may relieve anxiety and tension. A somewhat larger dose (e.g. 100 to 200 mg) will, in a tranquil setting, usually induce sleep. An equivalent dose in a social setting, however, may produce effects similar to those of drunkenness - a "high" feeling, slurred speech, staggering, slowed reactions, loss of inhibition, and intense emotions often expressed in an extreme and unpredictable manner. High doses characteristically produce slow, shallow, and irregular breathing, and can result in death from respiratory arrest.

Non-medical users often start taking barbiturates at doses within a safe therapeutic range. As tolerance develops, however, they progressively increase their daily dose to many times the original. It is extremely important to note that in spite of acquiring tolerance to the intoxicating effects of barbiturates, the user develops no tolerance to the lethal action of the drug Therefore, high doses could produce fatal results even for tolerant abusers.

Taking barbiturates with other CNS depressants - e.g. tranquillizers; such opioids as heroin, morphine, meperidine (Demerol), codeine, or methadone; and antihistamines (found in cold, cough, and allergy remedies) - can be extremely dangerous, even lethal.

No one should operate a motor vehicle or engage in tasks requiring concentration and coordination while under the influence of any CNS depressant.

The long-term effect of barbiturates - particularly of protracted high-dose abuse - is not unlike a state of chronic inebriation. Symptoms include the impairment of memory and judgment; hostility, depression, or mood swings; chronic fatigue; and stimulation of preexisting emotional disorders, which may result in paranoia or thoughts of suicide. Although the prescribing of barbiturates has declined notably since the safer benzodiazepine tranquillizers were introduced, this group of drugs remains a significant contributor to drug- related deaths. They remain easily available to abusers through both licit and illicit sources.
Other sedative/hypnothics
Such drugs as glutethimide (Doriden), methyprylon (Noludar), ethchlorvynol (Placidyl), and methaqualone (found in Mandrax) were introduced as barbiturate substitutes, in the belief they would be safer. It was soon found, however, that they shared problems similar to those of barbiturates, including abuse leading to overdose and interaction with other CNS depressants. The same caution necessary in using barbiturates thus applies to these other sedative/hypnotics as well.

Tolerance and dependence
Because tolerance to the intoxicating effects of sedative/ hypnotics can develop rapidly with regular use, higher daily doses become necessary to achieve the desired effects. Taking more of the drug to compensate for tolerance, however, can lead to life-threatening complications. On one hand, there is the risk of death from overdose. On the other, when chronic and regular high-dose abuse has resulted in serious physical dependence, abrupt withdrawal can cause symptoms severe enough to cause death. For this reason, barbiturates are among the most dangerous of the widely abused drugs.

People who use these drugs daily for prolonged periods may become both psychologically and physically dependent upon them.

Psychological dependence exists when a drug is so central to a person's thoughts, emotions, and activities that the need to continue its use becomes a craving or compulsion. Psychological dependence is most likely to occur with the fast-acting barbiturates, which can produce euphoria within minutes of being taken.

Physical dependence exists when the body has adapted to the presence of the drug, and withdrawal symptoms occur when its use is abruptly ended. These symptoms range in intensity from progressive restlessness, anxiety, insomnia, and irritability to delirium and convulsions in severe cases. Again, it must be stressed that physical dependence on barbiturates can be one of the most dangerous of all drug dependencies.

Barbiturates are commonly and heavily used by heroin addicts; they inject a mixture of both drugs to obtain a pleasurable "high" - a hazardous practice, because both drugs depress respiratory control centres in the brain. Some methamphetamine ("speed") abusers take barbiturates to combat severe hyperactivity following a "run" of methamphetamine use over several days.
Tranquillizers and Sleeping-pills- Tranquillizers and sleeping pills
Tranquillizers are depressant drugs that slow down the central nervous system (CNS), and thus are similar to such other CNS depressants as alcohol and barbiturates.

The term "major tranquillizer" was formerly applied to drugs used to treat severe mental illnesses, such as schizophrenia. However, these drugs are now more commonly called neuroleptics; their action specifically relieves the symptoms of mental illness, and they are rarely misused for other purposes. This paper therefore deals with the anti-anxiety agents, or anxiolytics (formerly called "minor" tranquillizers).

Anti-anxiety agents share many similarities with barbiturates; both are classified as sedative/hypnotics. These newer agents were introduced under the term "tranquillizer" because, it was claimed, they provided a calming effect without sleepiness. Today, tranquillizers have largely replaced barbiturates in the treatment of both anxiety and insomnia because they are safer and more effective. The degree of sleepiness induced depends on the dosage. Tranquillizers are also used as sedatives before some surgical and medical procedures, and they are sometimes used medically during alcohol withdrawal.

Although tranquillizers do not exhibit the serious dependence characteristics of barbiturates, they nevertheless can produce tolerance and dependence. They may also be misused and abused.

The first drug to be labelled a tranquillizer was meprobamate - under the trade name Miltown - in 1954. Today, however, the most popular anti-anxiety agents are the benzodiazepines (e.g. Valium, Halcion, and Ativan). (NOTE that where a drug name is capitalized, it is a registered trade name of the manufacturer.) Since the early 1960s, the benzodiazepines have accounted for more than half the total world sales of tranquillizers. They are currently the most commonly prescribed class of psychotropic (mood-altering) drugs in Canada.

The first benzodiazepine developed was chlordiazepoxide, which is sold under such trade names as Librium and Novopoxide. The next was diazepam; it is marketed, among other brand names, as Valium, E-Pam, and Vivol. In the early 1970s diazepam was the most widely prescribed drug in North America. Now Halcion and Ativan - drugs from the same family as diazepam but eliminated more rapidly from the body - account for most benzodiazepine prescriptions. There are 14 different benzodiazepines currently available in Canada. Some are prescribed as anti-anxiety drugs (e.g. Valium, Librium); others are recommended as sleeping medications (e.g. Dalmane, Somnol, Novoflupam, and Halcion).

Effects
The effects of any drug depend on several factors

* the amount taken at one time
* the user's past drug experience
* the manner in which the drug is taken

he circumstances under which the drug is taken (the place, the user's psychological and emotional stability, the presence of other people, the simultaneous use of alcohol or other drugs, etc.).

With tranquillizers, a therapeutic dose (i.e. what is medically prescribed) relieves anxiety and may, in some people, induce a loss of inhibition and a feeling of well-being. Responses vary, however. Some people report lethargy, drowsiness, or dizziness. Tranquillizers, though, have very few side effects.

As the dose of a tranquillizer is increased, so is sedation and impairment of mental acuity and physical coordination. Lower doses are recommended for older people or for those with certain chronic diseases, since their bodies tend to metabolize these drugs more slowly.

Studies show that anti-anxiety agents, even at the usually recommended and prescribed doses, may disrupt the user's ability to perform certain physical, intellectual, and perceptual functions. For these reasons, users should not operate a motor vehicle or engage in tasks calling for concentration and coordination. Such activities are particularly hazardous if tranquillizers are used together with alcohol and/or barbiturates (i.e. other sedative/hypnotics) or antihistamines (in cold, cough, and allergy remedies). These effects occur early in therapy, however, and wane over time with increased tolerance (when more of the drug is needed to produce the same effect).

Because some tranquillizers (such as diazepam) are metabolized quite slowly, residue can accumulate in body tissues with long- term use and can heighten such effects as lethargy and

sluggishness.
Toxic effects
Tranquillizer overdose, particularly with benzodiazepines, has become increasingly common since the 1960s. While these drugs are usually safe even when an overdose is taken (death rarely results from benzodiazepine use alone), they can be fatal in combination with alcohol and other drugs that depress the central nervous system.

In Canada, as elsewhere, tranquillizer-related poisonings and overdoses have kept pace with the drug's availability. It is a fact that the drugs used in suicide attempts are those most widely prescribed and available. (The majority of these drug-related suicide attempts are by women under 30.) 

Tolerance and dependence
Because tolerance to the mood-altering effects of tranquillizers can develop with regular use, higher daily doses become necessary to maintain the desired effects. Tolerance may occur even at prescribed doses.

Chronic users may become both psychologically and physically dependent on tranquillizers.

Psychological dependence exists when a drug is so central to a person's thoughts, emotions, and activities that the need to continue its use becomes a craving or compulsion.

With chronic use, especially at higher doses, physical dependence can also occur. The user's body has adapted to the presence of the drug and suffers withdrawal symptoms when use is stopped. The frequency and severity of the withdrawal syndrome depends on the dose, duration of use, and whether use is stopped abruptly or tapered off. Symptoms range in intensity from progressive anxiety, restlessness, insomnia, and irritability in mild cases to delirium and convulsions in severe cases.

Dependence may also occur following long-term therapeutic use, but withdrawal symptoms in such cases are mild. Patients complain of gastrointestinal problems, loss of appetite, sleep disturbances, sweating, trembling, weakness, anxiety, and changes in perception (e.g. increased sensitivity to light, sound, and smells).

Risk of dependency increases if tranquillizers are taken regularly for more than a few months, although problems have been reported within shorter periods. The onset and severity of withdrawal differ between the benzodiazepines that are rapidly eliminated from the body (e.g. Halcion) and those that are slowly eliminated (e.g. Valium). In the former case, symptoms appear within a few hours after stopping the drug and may be more severe. In the latter case, symptoms usually take a few days to appear.

Tranquillizers and pregnancy
If a woman uses tranquillizers regularly, the drug can affect the baby for up to 10 days after birth. Babies may exhibit the withdrawal symptoms common to such other depressant drugs as alcohol and barbiturates. These symptoms include feeding difficulties, disturbed sleep, sweating, irritability, and fever. Symptoms will be more severe if the doses the mother took are higher.

Administration of diazepam during labor has been linked to decreased responsiveness and respiratory problems in some newborns.

Who uses tranquillizers
A 1989 Addiction Research Foundation survey of Ontario adults aged 18 years and over indicated that 6.5% had used tranquillizers in the previous 12 months - roughly half the percentage of users reported in 1977.

The survey showed that women, as a group, use tranquillizers most frequently. A 1990 study done at the Foundation found that women who were abused as girls, or who saw their mothers abused by a male partner, were more likely, as adults, to use tranquillizers and also illegal drugs. The study found too that women who are abused by their partners use more tranquillizers - as well as more sedatives, sleeping pills, and alcohol - than other women.

Other frequent tranquillizer users are people over 50 (with those over 65 being the highest users); those with only elementary school education; people in the lowest income group; and those who marked their occupation category as "other" (which included people who are housewives and students, and those who are disabled, retired, or unemployed).

The study also showed that tranquillizer use by people 50 years and more remained at virtually a constant level from 1977 to 1984, but declined in 1987. For those between 18 and 29, use decreased steadily from 1977 to 1987.

In a separate Foundation study done in 1987, Ontario students in grades 7 to 13 were polled. The findings showed that 4.9% reported using prescribed tranquillizers, and 3% non-prescribed tranquillizers, at least once in the preceding year. The self reported rate of use was highest among 16- and 17-year-old students (6.3% for prescribed tranquillizers, and 4.5% for nonprescribed ones).

People dependent on alcohol or other drugs are at higher risk than others for tranquillizer abuse and dependence. Alcohol treatment and methadone maintenance programs report that their clients often abuse or are dependent on tranquillizers.

Amphetamine and cocaine users frequently take tranquillizers to relax or sleep after over-stimulation by the former drugs. Prescribing tranquillizers to users of other drugs, or to people undergoing withdrawal, carries a risk of transferring their dependence to tranquillizers. Dose and duration of treatment should be closely monitored.
Tobacco- Tobacco
Tobacco smoke components
Tobacco smoke is made up of thousands of components, the main ones being nicotine, tar and carbon monoxide. Nicotine is the addictive agent in tobacco, tar can cause cancers and bronchial disorders, and carbon monoxide contributes to heart disease.

Nicotine is a powerful mood-altering substance which reaches the brain quickly when you smoke a cigarette.

Nicotine is also extremely toxic. A dose of about 30 mg can be fatal. Although an average cigarette contains 15-20 mg of nicotine, only a fraction is absorbed by the smoker.

Smokers can control the intake of nicotine considerably by adjusting their smoking technique. Long, deep inhalations, more puffs per cigarette, smoking down to the butt, or blocking the filter airflow of an ultra-low-tar brand can increase the nicotine yield.

Tar is not a single ingredient; it is a dark sticky combination of hundreds of chemicals including poisons and cancer-causing substances. As with nicotine, the tar yield of a cigarette can be higher depending on how a cigarette is smoked.

Carbon Monoxide (CO) the poisonous emission from automobile engines is also formed when tobacco is burned. CO in smoke replaces the oxygen in red blood cells, forming carboxyhemoglobin (COHb). While nicotine causes the heart to work harder, COHb deprives it of the extra oxygen this work demands. Among the chemicals in cigarette smoke are acids, glycerol, glycol, alcohols, aldehydes, ketones, aliphatic and aromatic hydrocarbons, phenols, and such corrosive gases as hydrogen cyanide and nitrogen oxide, as well as a heavy dose of carbon monoxide. Heart and circulatory disease, lung and other cancers, and emphysema and chronic bronchitis have been linked to some of these substances

Effects of smoking
Short-term effects of smoking include a significant increase in heart rate and a drop in skin temperature. Respiration rate is also increased. In novice smokers, diarrhea and vomiting may occur. Although the central nervous system is, in fact, stimulated by smoking, smokers usually feel it relaxes them.

Long-term effects are mainly on the bronchopulmonary and cardiovascular systems. Smoking is the main cause of lung cancer (related to 90% of all lung cancer cases). Other factors - notably industrial carcinogens (e.g. asbestos) - may be involved, especially among smokers. An average smoker is 10 times more likely to get lung cancer than a non-smoker.

Smoking is estimated to be responsible for 30% of all cancer deaths. It is also associated with cancers of the mouth, throat, colon, pancreas, bladder, kidneys, stomach, and cervix, and related to 75% of chronic bronchitis cases and 80% of emphysema cases.

Tobacco also affects the digestive system - gastric and duodenal ulcers are twice as common and twice as likely to cause death in smokers as in non-smokers. Skin wounds may heal less quickly in smokers, partly because smoking depletes the body of vitamin C. Smokers may also have less effective immune systems than non-smokers.

Tobacco use is associated with 25% to 30% of all cardiovascular disease. Smokers have a 70% higher rate of coronary heart disease than non-smokers (it is the major smoking-related cause of death), nearly twice the risk of heart attack, and five times the risk of stroke.

The damaging effects of smoking are often increased by other factors: for example, the heavy use of such other drugs as alcohol with tobacco increases the risk of both tobacco-related cancer and other diseases of the heart and blood vessels.
Women and tobacco
Tobacco use during pregnancy increases the risk of such complications as stillbirths, low birth weights, premature delivery, miscarriage, and sudden infant death syndrome. Women who smoke may also experience reduced fertility, increased menstrual disorders, earlier onset of menopause, and an increased risk of cervical cancer.

Women who smoke and use birth control pills are especially vulnerable, particularly after age 30. They are 39 times more likely to suffer from stroke than non-smokers who do not use the pill, and are at higher risk of contacting other circulatory diseases. as well.
Nicotine Addiction
Tobacco use can lead to physical and psychological dependence on nicotine, particularly in cigarette smokers. The United States Surgeon General's 1988 report states that "cigarettes and other forms of tobacco are just as addicting as heroin and cocaine...."

People who are physically dependent on tobacco suffer a withdrawal reaction when they stop using it. Some signs of withdrawal are: irritability, anxiety, headaches, sleep disturbances (insomnia or drowsiness), difficulty concentrating, decreased heart rate and increased appetite, and a craving for nicotine. These symptoms can last from several days to several weeks. However, desire for a cigarette and relapse to smoking can occur months after quitting, indicating that, as with other drug use, factors in addition to physical dependence play a role in nicotine addiction. Environmental events or emotional states may become conditioned signals for cigarette use.

Quitting smoking
Although the majority of smokers want to reduce or stop smoking, attempts to do so often fail. The U.S. Surgeon General's 1988 report states that "...at least 60% of tobacco smokers have tried to quit at some time in their lives." Quitting is possible, however: the majority of people who have ever smoked give up cigarettes later in life. Although about 20% of would-be quitters stop on their first attempt, most people "give up" several times before finally stopping for good.

People who quit generally achieve the same health levels as nonsmokers after a few years, especially if they stop while they are young. Risk of heart disease drops immediately; risk of lung cancer declines more gradually. Some lung disease may not be completely reversible, but even older lifetime smokers can benefit significantly from quitting.

There is no simple "cure" for smoking. It helps to find a personal reason. Cutting down or switching to ultra-low-yield brands instead of quitting may reduce exposure to smoke products, but many people just change the way they smoke - they take more or longer puffs - to get the same effect. Withdrawal symptoms subside more quickly for smokers who quit all at once than for those who gradually cut down.

Most quitters stop on their own - sometimes with the help of books, pamphlets, guides, or videos. Some prefer group support or professional counselling from a doctor, a smoking clinic, or a local health agency. No single method works for everyone; several different approaches may have to be tried.

Nicorette, a prescription gum containing nicotine, has helped some people deal with withdrawal symptoms, particularly those who are very dependent on nicotine. Other non-prescription anti-smoking products have not been shown scientifically to be effective.

Many smokers worry about weight gain if they stop smoking. Studies show that many of those who quit gain weight, but the gain is usually only a few kilograms, and can be minimized by exercising and eating low-fat foods.
Alcohol-Alcohol
Alcohol is often not thought of as a drug - largely because its use is common for both religious and social purposes in most parts of the world. It is an addictive drug, however, and compulsive drinking in excess has become one of modern society's most serious problems.

Beverage alcohol (scientifically known as ethyl alcohol, or ethanol) is produced by fermenting or distilling various fruits, vegetables, or grains. Ethyl alcohol itself is a clear, colorless liquid. Alcoholic beverages get their distinctive colors from the diluents, additives, and by-products of fermentation.

Beer is fermented to contain about 5% alcohol by volume (or 3.5% in light beer). Most wine is fermented to have between 10% and 14% alcohol content; however, such fortified wines as sherry, port, and vermouth contain between 14% and 20%. Distilled spirits (whisky, vodka, rum, gin) are first fermented, then distilled to raise the alcohol content. The concentration of alcohol in spirits is 40% by volume. Some liqueurs may be stronger.

The effects of drinking do not depend on the type of alcoholic beverage - but rather on the amount of alcohol consumed on a specific occasion.
How Alcohol Works
Alcohol- is rapidly absorbed into the bloodstream from the small intestine, and less rapidly from the stomach and colon. In proportion to its concentration in the bloodstream, alcohol decreases activity in parts of the brain and spinal cord. The drinker's blood alcohol concentration depends on:

* the amount consumed in a given time
* the drinker's size, sex, body build, and metabolism
* the type and amount of food in the stomach.

Once the alcohol has passed into the blood, however, no food or beverage can retard or interfere with its effects. Fruit sugar, however, in some cases can shorten the duration of alcohol's effect by speeding up its elimination from the blood.

In the average adult, the rate of metabolism is about 8.5 g of alcohol per hour (i.e. about two-thirds of a regular beer or about 30 mL of spirits an hour). This rate can vary dramatically among individuals, however, depending on such diverse factors as usual amount of drinking, physique, sex, liver size, and genetic factors.
Effects
# The effects of any drug depend on several factors: the amount taken at one time
# the user's past drug experience
# the manner in which the drug is taken
# the circumstances under which the drug is taken (the place, the user's psychological and emotional stability, the presence of other people, the concurrent use of other drugs, etc.).

It is the amount of alcohol in the blood that causes the effects. In the following table, the left-hand column lists the number of milligrams of alcohol in each decilitre of blood - that is, the blood alcohol concentration, or BAC. (For example, an average person may get a blood alcohol concentration of 50 mg/dL after two drinks consumed quickly.) The right-hand column describes the usual effects of these amounts on normal people - those who haven't developed a tolerance to alcohol.

BAC (ma/dL) Effect
50
Mild intoxication; Feeling of warmth, skin flushed; impaired judgment; decreased inhibitions
100
Obvious intoxication in most people; Increased impairment of judgment, inhibition, attention, and control; Some impairment of muscular performance; slowing of reflexes
150
Obvious intoxication in all normal people; Staggering gait and other muscular incoordination; slurred speech; double vision; memory and comprehension loss
250
Extreme intoxication or stupor; Reduced response to stimuli; inability to stand; vomiting; incontinence; sleepiness
350
Coma; Unconsciousness; little response to stimuli; incontinence; low body temperature; poor respiration; fall in blood pressure; clammy skin
500
Death likely

Drinking heavily over a short period of time usually results in a "hangover" - headache, nausea, shakiness, and sometimes vomiting, beginning from 8 to 12 hours later. A hangover is due partly to poisoning by alcohol and other components of the drink, and partly to the body's reaction to withdrawal from alcohol. Although there are dozens of home remedies suggested for hangovers, there is currently no known effective cure.

Combining alcohol with other drugs can make the effects of these other drugs much stronger and more dangerous. Many accidental deaths have occurred after people have used alcohol combined with other drugs.

Long-term effects of alcohol appear after repeated use over a period of many months or years. The negative physical and psychological effects of chronic abuse are numerous; some are potentially life-threatening.

Some of these harmful consequences are primary - that is, they result directly from prolonged exposure to alcohol's toxic effects (such as heart and liver disease or inflammation of the stomach).

Others are secondary; indirectly related to chronic alcohol abuse, they include loss of appetite, vitamin deficiencies, infections, and sexual impotence or menstrual irregularities. The risk of serious disease increases with the amount of alcohol consumed.

Early death rates are much higher for heavy drinkers than for light drinkers or abstainers, particularly from heart and liver disease, pneumonia, some types of cancer, acute alcohol poisoning, accident, homicide, and suicide. No precise limits of safe drinking can be recommended.

Tolerance and Dependence
People who drink on a regular basis become tolerant to many of the unpleasant effects of alcohol, and thus are able to drink more before suffering these effects. Yet even with increased consumption, many such drinkers don't appear intoxicated. Because they continue to work and socialize reasonably well, their deteriorating physical condition may go unrecognized by others until severe damage develops - or until they are hospitalized for other reasons and suddenly experience alcohol withdrawal symptoms.

Psychological dependence on alcohol may occur with regular use of even relatively moderate daily amounts. It may also occur in people who consume alcohol only under certain conditions, such as before and during social occasions. This form of dependence refers to a craving for alcohol's psychological effects, although not necessarily in amounts that produce serious intoxication. For psychologically dependent drinkers, the lack of alcohol tends to make them anxious and, in some cases, panicky.

Physical dependence occurs in consistently heavy drinkers. Since their bodies have adapted to the presence of alcohol, they suffer withdrawal symptoms if they suddenly stop drinking. Withdrawal symptoms range from jumpiness, sleeplessness, sweating, and poor appetite, to tremors (the "shakes"), convulsions. hallucinations. and sometimes death.

Alcohol and Pregnancy
Pregnant women who drink risk having babies with fetal alcohol effects (known as fetal alcohol syndrome or FAS). The most serious of these effects include mental retardation, growth deficiency, head and facial deformities, joint and limb abnormalities, and heart defects. While it is known that the risk of bearing an FAS-afflicted child increases with the amount of alcohol consumed, a safe level of consumption has not been determined
Caffeine-Facts about: caffeine
Caffeine is the world's most popular drug. The white, bitter-tasting, crystalline substance was first isolated from coffee in 1820. Both words, caffeine and coffee, are derived from the Arabic word qahweh (pronounced "kahveh" in Turkish). The origins of the words reflect the spread of the beverage into Europe via Arabia and Turkey from north-east Africa, where coffee trees were cultivated in the 6th century. Coffee began to be popular in Europe in the 17th century. By the 18th century plantations had been established in Indonesia and the West Indies.

The caffeine content of coffee beans varies according to the species of the coffee plant. Beans from Coffee arabica, grown mostly in Central and South America, contain about 1.1% caffeine. Beans from Coffee robusta, grown mostly in Indonesia and Africa, contain about 2.2% caffeine. Caffeine also occurs in cacao pods and hence in cocoa and chocolate products; in kola nuts, used in the preparation of cola drinks; and in the ilex plant, from whose leaves the popular South American beverage yerba mate is prepared.

Caffeine is also found in tea. It was first isolated from tea leaves in 1827 and named "theine" because it was believed to be a distinctly different compound from the caffeine in coffee. Tea leaves contain about 3.5% caffeine, but a cup of tea usually contains less caffeine than a cup of coffee because much less tea than coffee is used during preparation.

In North America, the caffeine content of a cup of coffee averages about 75 mg, but varies widely according to cup size, the method of preparation, and the amount of coffee used. Generally, cups prepared from instant coffee contain less caffeine (average 65 mg) and cups prepared by drip methods contain more caffeine (average 110 mg). Cups of tea average about 30 mg, but the range is also largeþfrom 10 to 90 mg.

Cola drinks contain about 35 mg caffeine per standard 280 mL serving, with some 5% of the caffeine being a component of kola nuts and most of the remainder being added in the form of a by-product of the decaffeination of coffee and tea. Caffeine- containing soft drinks account for more than 65% of soft drink consumption. A cup of hot chocolate contains about 4 mg caffeine, and a 50-gram chocolate bar between 5 and 60 mg, increasing with the quality of the chocolate. Caffeine is an ingredient of certain headache pills (30-65 mg). It is the main ingredient of non-prescription "stay-awake" pills (100-200 mg).

Short-term Effects
Caffeine taken in beverage form begins to reach all tissues of the body within five minutes. Peak blood levels are reached in about 30 minutes. Half of a given dose of caffeine is metabolized in about four hours þ more rapidly in smokers and less rapidly in newborn infants, in women in late pregnancy, and in sufferers from liver disease. Normally, almost all ingested caffeine is metabolized. Less than 3% appears unchanged in urine, and the


Last edited by connor122 ; edited 1 time in total
#4. Posted:
i-Flux
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connor122 wrote using!! FOR FUTURE REFERENCE!!!!


Ouch, fail? Did I take that place... Sorry!
#5. Posted:
DaleUK
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Motto: Fun Fact: You have a 1 in 20 chance that your house will burn down once you become a staff member!
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Motto: Fun Fact: You have a 1 in 20 chance that your house will burn down once you become a staff member!
Can i ask, what was the whole point of this massive copy/paste ?
#6. Posted:
EzMoneY
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copy and paste much
lol. its ok
#7. Posted:
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There is no way in hell im gonna read all that :/

Maybe summarize it for me?
#8. Posted:
GeoRdiiE
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seriously what was the point of this, most of i knew anyways

-

Luke
#9. Posted:
iTroll
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There was no point to this lol. but i guess it was an ok post....??
#10. Posted:
iTroll
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iLike where its just DONT TAKE MAGIC MUSHROOMS lol thought tht was funny
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