~Clear the D.U.P. completely out of a district~

There are a total of 13 districts to clear in the game. To clear all the D.U.P. out of a district you must destroy the D.U.P. mobile command, do all side activities, find all collectibles and complete the final showdown. All of these things will be marked on your in-game world map once you destroy the D.U.P. mobile command. It will roughly take 15-20 minutes to clear a district.