You will spend a whole mission using the TDV-1 to make your way through the level. This achievement sounds fairly easy and straightforward but can be a hassle. As you drive your turret will shoot down all enemies which are in your way. Unless you are quick the turret will finish off the enemies before you can run them over.

You may want to replay checkpoints or even attempt this on Hardcore as enemies will be tougher and take more shots from the turret. Successfully run over 25 enemies and the achievement will unlock.