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Gamerscore: 25G
Achievement Description: Completed every unique round in Real Big Shootin'.

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There are 11 types of special conditions and 12 different levels (not including the boss level). Each level has 2-3 different variants. You will have to go through several playthroughs to get all of these as these are chosen randomly. You will get "Real Big Specialin'" while going for this. The different special conditions are:

Nothing - Nothing is changed.
Shotgun Showdown - Your weapon is a shotgun
Flamethrower Frenzy - Your weapon is a flamethrower
Turbo - Enemies move faster
Metal Dudes - Enemies require two shots to kill
Single Shots - You only get to target one enemy at a time
Tiny Gun - Smaller reticle
Lefty Flip - You have to shoot with your left hand
Backwards Flip - Aiming right and left are reversed
Dual Pistols - You get two guns, one per hand
Auto Guns - Guns fire automatically