Cause 10,000 damage with Guns.

This one is perhaps the most straightforward of the group. Simply take a gun that uses bullets and shoot enemies. For best results, you'll want to fight against lightly armored opponents like Raiders, Fiends, and Great Khans. Also remember that unless you want to wait for the Weapon Handling (Level 16, Strength under 10) perk you'll need a Strength of at least 3, though up to 5-8 if you want versatility in weapon choices.